Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia
Though both neuropathy and fibromyalgia are serious complications that cause widespread pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic disorders, chemotherapy, and neurotoxic exposure are frequently reported with neuropathic pain, whereas inflammatory...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622003309 |
| _version_ | 1811208691426263040 |
|---|---|
| author | Garima Mishra Pradeep Singh Mulugeta Molla Yohannes Shumet Yimer Amien Ewunetie Tesfaye Yimer Tadesse Teklie Mengie Ayele Belayneh Kefale |
| author_facet | Garima Mishra Pradeep Singh Mulugeta Molla Yohannes Shumet Yimer Amien Ewunetie Tesfaye Yimer Tadesse Teklie Mengie Ayele Belayneh Kefale |
| author_sort | Garima Mishra |
| collection | DOAJ |
| description | Though both neuropathy and fibromyalgia are serious complications that cause widespread pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic disorders, chemotherapy, and neurotoxic exposure are frequently reported with neuropathic pain, whereas inflammatory and musculoskeletal diseases are associated with fibromyalgia. In recent years, these pain syndromes have become a significant challenge for healthcare experts due to their complex etiology, limited drug availability, and effectiveness. Notably, pharmaceutical drugs (antidepressants, anticonvulsants) available today have adverse effects, including physical dependence and tolerance. Therefore, a plethora of nutraceuticals has drawn considerable attention from patients seeking relief from chronic pain conditions. Nonetheless, only a few preclinical and clinical studies have been conducted to establish the safety and efficacy of these supplements. The current review concentrates on the role of a variety of nutraceuticals in the treatment of neuropathic pain and fibromyalgia, as well as their potential mechanisms and clinical trials. |
| first_indexed | 2024-04-12T04:26:54Z |
| format | Article |
| id | doaj.art-993fd53d7e8b4269ac72ec7abe135e79 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-12T04:26:54Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-993fd53d7e8b4269ac72ec7abe135e792022-12-22T03:48:04ZengElsevierJournal of Functional Foods1756-46462022-10-0197105260Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgiaGarima Mishra0Pradeep Singh1Mulugeta Molla2Yohannes Shumet Yimer3Amien Ewunetie4Tesfaye Yimer Tadesse5Teklie Mengie Ayele6Belayneh Kefale7Pharmaceutical Chemistry Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; Corresponding author.Pharmaceutical Chemistry Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaSocial Pharmacy Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaPharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaClinical Pharmacy Unit, Department of Pharmacy, College of Medical and Health Sciences, Bahir Dar University, Bahir Dar, EthiopiaThough both neuropathy and fibromyalgia are serious complications that cause widespread pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic disorders, chemotherapy, and neurotoxic exposure are frequently reported with neuropathic pain, whereas inflammatory and musculoskeletal diseases are associated with fibromyalgia. In recent years, these pain syndromes have become a significant challenge for healthcare experts due to their complex etiology, limited drug availability, and effectiveness. Notably, pharmaceutical drugs (antidepressants, anticonvulsants) available today have adverse effects, including physical dependence and tolerance. Therefore, a plethora of nutraceuticals has drawn considerable attention from patients seeking relief from chronic pain conditions. Nonetheless, only a few preclinical and clinical studies have been conducted to establish the safety and efficacy of these supplements. The current review concentrates on the role of a variety of nutraceuticals in the treatment of neuropathic pain and fibromyalgia, as well as their potential mechanisms and clinical trials.http://www.sciencedirect.com/science/article/pii/S1756464622003309FibromyalgiaNeuropathic painNeurotransmittersNutraceuticalsSpinal cord injurySpared nerve injury |
| spellingShingle | Garima Mishra Pradeep Singh Mulugeta Molla Yohannes Shumet Yimer Amien Ewunetie Tesfaye Yimer Tadesse Teklie Mengie Ayele Belayneh Kefale Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia Journal of Functional Foods Fibromyalgia Neuropathic pain Neurotransmitters Nutraceuticals Spinal cord injury Spared nerve injury |
| title | Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia |
| title_full | Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia |
| title_fullStr | Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia |
| title_full_unstemmed | Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia |
| title_short | Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia |
| title_sort | nutraceuticals a source of benefaction for neuropathic pain and fibromyalgia |
| topic | Fibromyalgia Neuropathic pain Neurotransmitters Nutraceuticals Spinal cord injury Spared nerve injury |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622003309 |
| work_keys_str_mv | AT garimamishra nutraceuticalsasourceofbenefactionforneuropathicpainandfibromyalgia AT pradeepsingh nutraceuticalsasourceofbenefactionforneuropathicpainandfibromyalgia AT mulugetamolla nutraceuticalsasourceofbenefactionforneuropathicpainandfibromyalgia AT yohannesshumetyimer nutraceuticalsasourceofbenefactionforneuropathicpainandfibromyalgia AT amienewunetie nutraceuticalsasourceofbenefactionforneuropathicpainandfibromyalgia AT tesfayeyimertadesse nutraceuticalsasourceofbenefactionforneuropathicpainandfibromyalgia AT tekliemengieayele nutraceuticalsasourceofbenefactionforneuropathicpainandfibromyalgia AT belaynehkefale nutraceuticalsasourceofbenefactionforneuropathicpainandfibromyalgia |