Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic Elderly
Aim:Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases in older adults. With advancing age, polypharmacy and protein-energy malnutrition associated with chronic diseases can be seen frequently in T2DM patients due to metabolic causes and may adversely affect the prognosis. In...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2022-06-01
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| Series: | Namık Kemal Tıp Dergisi |
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http://namikkemalmedj.com/archives/archive-detail/article-preview/evaluation-of-the-relationship-between-polypharmac/52167
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| _version_ | 1797918910918426624 |
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| author | Funda DATLI YAKARYILMAZ Ayten ERAYDIN |
| author_facet | Funda DATLI YAKARYILMAZ Ayten ERAYDIN |
| author_sort | Funda DATLI YAKARYILMAZ |
| collection | DOAJ |
| description | Aim:Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases in older adults. With advancing age, polypharmacy and protein-energy malnutrition associated with chronic diseases can be seen frequently in T2DM patients due to metabolic causes and may adversely affect the prognosis. In this study, it was aimed to evaluate the relationship between polypharmacy and malnutrition in T2DM patients.Materials and Methods:Three hundred and twenty-one patients aged 65 years and over, diagnosed with T2DM and receiving oral anti-diabetic drug therapy, who applied to the Internal Medicine and Geriatrics outpatient clinic between February and November 2021, were included in the study. The data of the patients were obtained retrospectively from their medical files. The use of 5 or more drugs was considered as polypharmacy. Mini Nutritional Assessment-short form (MNA-SF) was used for nutritional status assessment.Results:The median number of concomitant medications used in patients followed up with the diagnosis of T2DM was 5. Polypharmacy was found in 209 (65.1%) patients, and severe polypharmacy was found in 21 (6.5%) patients. Malnutrition was found in 43 (20.6%) patients with polypharmacy, while 17 (80.1%) of 21 patients with severe polypharmacy had malnutrition. A positive correlation was found between the number of drugs and HbA1c, and a negative correlation with the MNA-SF score (r=0.792, p<0.001, r=-0.317, p<0.001, respectively). According to the logistic regression analysis, the presence of HbA1c and polypharmacy were found to be effective factors in the development of malnutrition (p=0.009, p=0.002).Conclusion:Current findings show that polypharmacy is quite common in elderly T2DM patients and often accompanies malnutrition. It is important to review the drugs used in each visit and to evaluate malnutrition that may be related to newly started or currently used drugs so that intertwined polypharmacy and malnutrition are not overlooked in elderly patients. |
| first_indexed | 2024-04-10T13:36:55Z |
| format | Article |
| id | doaj.art-99408ff2f7944b9ba6aedf5c3ada2791 |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T13:36:55Z |
| publishDate | 2022-06-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-99408ff2f7944b9ba6aedf5c3ada27912023-02-15T16:11:21ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622022-06-0110219920510.4274/nkmj.galenos.2022.1948313049054Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic ElderlyFunda DATLI YAKARYILMAZ0Ayten ERAYDIN1 İnönü Üniversitesi Tıp Fakültesi, Geriatri Anabilim Dalı, Malatya, Türkiye Pamukkale Üniversitesi Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Denizli, Türkiye Aim:Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases in older adults. With advancing age, polypharmacy and protein-energy malnutrition associated with chronic diseases can be seen frequently in T2DM patients due to metabolic causes and may adversely affect the prognosis. In this study, it was aimed to evaluate the relationship between polypharmacy and malnutrition in T2DM patients.Materials and Methods:Three hundred and twenty-one patients aged 65 years and over, diagnosed with T2DM and receiving oral anti-diabetic drug therapy, who applied to the Internal Medicine and Geriatrics outpatient clinic between February and November 2021, were included in the study. The data of the patients were obtained retrospectively from their medical files. The use of 5 or more drugs was considered as polypharmacy. Mini Nutritional Assessment-short form (MNA-SF) was used for nutritional status assessment.Results:The median number of concomitant medications used in patients followed up with the diagnosis of T2DM was 5. Polypharmacy was found in 209 (65.1%) patients, and severe polypharmacy was found in 21 (6.5%) patients. Malnutrition was found in 43 (20.6%) patients with polypharmacy, while 17 (80.1%) of 21 patients with severe polypharmacy had malnutrition. A positive correlation was found between the number of drugs and HbA1c, and a negative correlation with the MNA-SF score (r=0.792, p<0.001, r=-0.317, p<0.001, respectively). According to the logistic regression analysis, the presence of HbA1c and polypharmacy were found to be effective factors in the development of malnutrition (p=0.009, p=0.002).Conclusion:Current findings show that polypharmacy is quite common in elderly T2DM patients and often accompanies malnutrition. It is important to review the drugs used in each visit and to evaluate malnutrition that may be related to newly started or currently used drugs so that intertwined polypharmacy and malnutrition are not overlooked in elderly patients. http://namikkemalmedj.com/archives/archive-detail/article-preview/evaluation-of-the-relationship-between-polypharmac/52167 diabetes mellituspolypharmacymalnutritionelderly patients |
| spellingShingle | Funda DATLI YAKARYILMAZ Ayten ERAYDIN Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic Elderly Namık Kemal Tıp Dergisi diabetes mellitus polypharmacy malnutrition elderly patients |
| title | Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic Elderly |
| title_full | Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic Elderly |
| title_fullStr | Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic Elderly |
| title_full_unstemmed | Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic Elderly |
| title_short | Evaluation of the Relationship Between Polypharmacy and Malnutrition in Diabetic Elderly |
| title_sort | evaluation of the relationship between polypharmacy and malnutrition in diabetic elderly |
| topic | diabetes mellitus polypharmacy malnutrition elderly patients |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/evaluation-of-the-relationship-between-polypharmac/52167
|
| work_keys_str_mv | AT fundadatliyakaryilmaz evaluationoftherelationshipbetweenpolypharmacyandmalnutritionindiabeticelderly AT ayteneraydin evaluationoftherelationshipbetweenpolypharmacyandmalnutritionindiabeticelderly |