S-Adenosylmethionine Increases the Sensitivity of Human Colorectal Cancer Cells to 5-Fluorouracil by Inhibiting P-Glycoprotein Expression and NF-κB Activation

S-Adenosylmethionine Increases the Sensitivity of Human Colorectal Cancer Cells to 5-Fluorouracil by Inhibiting P-Glycoprotein Expression and NF-κB Activation

Colorectal cancer (CRC) is the second deadliest cancer worldwide despite significant advances in both diagnosis and therapy. The high incidence of CRC and its poor prognosis, partially attributed to multi-drug resistance and antiapoptotic activity of cancer cells, arouse strong interest in the ident...

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Bibliographic Details
Main Authors: Laura Mosca, Martina Pagano, Luigi Borzacchiello, Luigi Mele, Annapina Russo, Giulia Russo, Giovanna Cacciapuoti, Marina Porcelli
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
S-Adenosylmethionine
colorectal cancer
5-Fluorouracil
multidrug resistance
P-glycoprotein
combination therapy
Online Access:https://www.mdpi.com/1422-0067/22/17/9286

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