Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity.

Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity.

Seasonal epidemics of influenza virus result in ∼36,000 deaths annually in the United States. Current vaccines against influenza virus elicit an antibody response specific for the envelope glycoproteins. However, high mutation rates result in the emergence of new viral serotypes, which elude neutral...

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Bibliographic Details
Main Authors: Brian J Laidlaw, Vilma Decman, Mohammed-Alkhatim A Ali, Michael C Abt, Amaya I Wolf, Laurel A Monticelli, Krystyna Mozdzanowska, Jill M Angelosanto, David Artis, Jan Erikson, E John Wherry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3597515?pdf=render

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