Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers
The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-03-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520354493 |
| _version_ | 1819060721616420864 |
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| author | Aruna Gorusupudi Aihua Liu Gregory S. Hageman Paul S. Bernstein |
| author_facet | Aruna Gorusupudi Aihua Liu Gregory S. Hageman Paul S. Bernstein |
| author_sort | Aruna Gorusupudi |
| collection | DOAJ |
| description | The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease remains controversial. In this study, we examined two independent cohorts of donor eyes and related their retinal lipid profiles with systemic biomarkers of lipid intake. We found that serum and red blood cell lipids, and to a lesser extent orbital fat, are indeed excellent biomarkers of retinal lipid content and n-3/n-6 ratios in both the LC-PUFA and VLC-PUFA series. Eyes from age-related macular degeneration (AMD) donors have significantly decreased levels of VLC-PUFAs and low n-3/n-6 ratios. These results are consistent with the protective role of dietary n-3 LC-PUFAs against AMD and emphasize the importance of monitoring systemic biomarkers of lipid intake when undertaking clinical trials of lipid supplements for prevention and treatment of retinal disease. |
| first_indexed | 2024-12-21T14:31:30Z |
| format | Article |
| id | doaj.art-9944ccae6a634067adaab29829e74d68 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-21T14:31:30Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-9944ccae6a634067adaab29829e74d682022-12-21T19:00:29ZengElsevierJournal of Lipid Research0022-22752016-03-01573499508Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkersAruna Gorusupudi0Aihua Liu1Gregory S. Hageman2Paul S. Bernstein3John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132; Sharon Eccles Steele Center for Translational Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132To whom correspondence should be addressed; John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132; Sharon Eccles Steele Center for Translational Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease remains controversial. In this study, we examined two independent cohorts of donor eyes and related their retinal lipid profiles with systemic biomarkers of lipid intake. We found that serum and red blood cell lipids, and to a lesser extent orbital fat, are indeed excellent biomarkers of retinal lipid content and n-3/n-6 ratios in both the LC-PUFA and VLC-PUFA series. Eyes from age-related macular degeneration (AMD) donors have significantly decreased levels of VLC-PUFAs and low n-3/n-6 ratios. These results are consistent with the protective role of dietary n-3 LC-PUFAs against AMD and emphasize the importance of monitoring systemic biomarkers of lipid intake when undertaking clinical trials of lipid supplements for prevention and treatment of retinal disease.http://www.sciencedirect.com/science/article/pii/S0022227520354493eyeretinadiet and dietary lipidsomega-3 fatty acidsnutritionmass spectrometry |
| spellingShingle | Aruna Gorusupudi Aihua Liu Gregory S. Hageman Paul S. Bernstein Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers Journal of Lipid Research eye retina diet and dietary lipids omega-3 fatty acids nutrition mass spectrometry |
| title | Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers |
| title_full | Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers |
| title_fullStr | Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers |
| title_full_unstemmed | Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers |
| title_short | Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers |
| title_sort | associations of human retinal very long chain polyunsaturated fatty acids with dietary lipid biomarkers |
| topic | eye retina diet and dietary lipids omega-3 fatty acids nutrition mass spectrometry |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520354493 |
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