Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls—Results from a Cross-Sectional Pilot Study
Oxidative stress describes an imbalance of reactive oxygen species (ROS) and antioxidative defence systems. Recently, the consequences of oxidative stress have become a central field of research and have been linked to the genesis of multiple psychiatric diseases. Some oxidative stress parameters ha...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/5/842 |
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| author | Jolana Wagner-Skacel Fiona Haidacher Markus Wiener Karoline Pahsini Sabine Marinschek Theresa Lahousen Willibald Wonisch Susanne Bengesser Mary I. Butler Sonja Lackner Andreas Meinitzer Dietmar Enko Sabrina Mörkl |
| author_facet | Jolana Wagner-Skacel Fiona Haidacher Markus Wiener Karoline Pahsini Sabine Marinschek Theresa Lahousen Willibald Wonisch Susanne Bengesser Mary I. Butler Sonja Lackner Andreas Meinitzer Dietmar Enko Sabrina Mörkl |
| author_sort | Jolana Wagner-Skacel |
| collection | DOAJ |
| description | Oxidative stress describes an imbalance of reactive oxygen species (ROS) and antioxidative defence systems. Recently, the consequences of oxidative stress have become a central field of research and have been linked to the genesis of multiple psychiatric diseases. Some oxidative stress parameters have not been investigated before in anorexia nervosa (AN) patients, including the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) and polyphenols (PPm). In this cross-sectional pilot study, we evaluated these markers together with total peroxides (TOC), antioxidative capacity (TAC), endogenous peroxidase activity (EPA) and antibodies against oxidized LDL (oLAb) in serum samples of 20 patients with AN compared to 20 healthy controls. The antioxidative capacity was significantly decreased in AN patients, with a mean TAC of 1.57 mmol/L (SD: ±0.62); t (34) = −2.181, <i>p</i> = 0.036) compared to HC (mean = 1.91 mmol/L (SD: ±0.56), while the other investigated parameters were not significantly different between the two groups. In AN patients, TAC correlated with EPA (r<sub>sp</sub> = −0.630, <i>p</i> = 0.009). This study suggests that there is an antioxidative deficiency in AN patients. In this respect, there is a demand for interventional studies to determine whether antioxidants can be used as add-on therapy in the treatment of AN. |
| first_indexed | 2024-03-10T03:26:31Z |
| format | Article |
| id | doaj.art-99480e8ff48c45dfa823c32f6a871e08 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T03:26:31Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-99480e8ff48c45dfa823c32f6a871e082023-11-23T09:50:37ZengMDPI AGAntioxidants2076-39212022-04-0111584210.3390/antiox11050842Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls—Results from a Cross-Sectional Pilot StudyJolana Wagner-Skacel0Fiona Haidacher1Markus Wiener2Karoline Pahsini3Sabine Marinschek4Theresa Lahousen5Willibald Wonisch6Susanne Bengesser7Mary I. Butler8Sonja Lackner9Andreas Meinitzer10Dietmar Enko11Sabrina Mörkl12Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaDivision of Physiological Chemistry, Medical University of Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaDepartment of Psychiatry and Neurobehavioral Science, University College Cork, T12 YT20 Cork, IrelandDivision of Immunology and Pathophysiology, Otto Loewi Research Center, Medical University of Graz, 8036 Graz, AustriaDivision of Medical and Clinical Laboratory Diagnostics, Medical University Graz, 8036 Graz, AustriaDivision of Medical and Clinical Laboratory Diagnostics, Medical University Graz, 8036 Graz, AustriaDepartment of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaOxidative stress describes an imbalance of reactive oxygen species (ROS) and antioxidative defence systems. Recently, the consequences of oxidative stress have become a central field of research and have been linked to the genesis of multiple psychiatric diseases. Some oxidative stress parameters have not been investigated before in anorexia nervosa (AN) patients, including the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) and polyphenols (PPm). In this cross-sectional pilot study, we evaluated these markers together with total peroxides (TOC), antioxidative capacity (TAC), endogenous peroxidase activity (EPA) and antibodies against oxidized LDL (oLAb) in serum samples of 20 patients with AN compared to 20 healthy controls. The antioxidative capacity was significantly decreased in AN patients, with a mean TAC of 1.57 mmol/L (SD: ±0.62); t (34) = −2.181, <i>p</i> = 0.036) compared to HC (mean = 1.91 mmol/L (SD: ±0.56), while the other investigated parameters were not significantly different between the two groups. In AN patients, TAC correlated with EPA (r<sub>sp</sub> = −0.630, <i>p</i> = 0.009). This study suggests that there is an antioxidative deficiency in AN patients. In this respect, there is a demand for interventional studies to determine whether antioxidants can be used as add-on therapy in the treatment of AN.https://www.mdpi.com/2076-3921/11/5/842anorexia nervosaoxidative stresstotal oxidative capacitytotal antioxidative capacityendogenous peroxidaseantibodies against oxidized LDL |
| spellingShingle | Jolana Wagner-Skacel Fiona Haidacher Markus Wiener Karoline Pahsini Sabine Marinschek Theresa Lahousen Willibald Wonisch Susanne Bengesser Mary I. Butler Sonja Lackner Andreas Meinitzer Dietmar Enko Sabrina Mörkl Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls—Results from a Cross-Sectional Pilot Study Antioxidants anorexia nervosa oxidative stress total oxidative capacity total antioxidative capacity endogenous peroxidase antibodies against oxidized LDL |
| title | Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls—Results from a Cross-Sectional Pilot Study |
| title_full | Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls—Results from a Cross-Sectional Pilot Study |
| title_fullStr | Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls—Results from a Cross-Sectional Pilot Study |
| title_full_unstemmed | Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls—Results from a Cross-Sectional Pilot Study |
| title_short | Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls—Results from a Cross-Sectional Pilot Study |
| title_sort | oxidative status in adult anorexia nervosa patients and healthy controls results from a cross sectional pilot study |
| topic | anorexia nervosa oxidative stress total oxidative capacity total antioxidative capacity endogenous peroxidase antibodies against oxidized LDL |
| url | https://www.mdpi.com/2076-3921/11/5/842 |
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