The epigenetic factor CHD4 contributes to metastasis by regulating the EZH2/β-catenin axis and acts as a therapeutic target in ovarian cancer

The epigenetic factor CHD4 contributes to metastasis by regulating the EZH2/β-catenin axis and acts as a therapeutic target in ovarian cancer

Abstract Background The overall survival rate of patients with advanced ovarian cancer (OC) has remained static for several decades. Advanced ovarian cancer is known for its poor prognosis due to extensive metastasis. Epigenetic alterations contribute to tumour progression and therefore are of inter...

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Bibliographic Details
Main Authors: Jieyu Wang, Fangfang Zhong, Jun Li, Huiran Yue, Wenzhi Li, Xin Lu
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Translational Medicine
Subjects:
Chromodomain-helicase-DNA-binding protein 4
Ovarian cancer
Histone deacetylase inhibitor
Romidepsin
Metastases
Online Access:https://doi.org/10.1186/s12967-022-03854-1

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