CysLT<sub>2</sub>R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils

CysLT<sub>2</sub>R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils

Post-stroke depression (PSD) is a kind of prevalent emotional disorder following stroke that usually results in slow functional recovery and even increased mortality. We had reported that the cysteinyl leukotriene receptor 2 (CysLT<sub>2</sub>R) antagonist HAMI3379 (HM3379) contributes t...

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Bibliographic Details
Main Authors: Li Zhou, Jiajia Zhang, Xue Han, Jie Fang, Shasang Zhou, Lingqun Lu, Qiaojuan Shi, Huazhong Ying
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Brain Sciences
Subjects:
cysteinyl leukotriene receptor 2
HAMI 3379
post-stroke depression
neuroinflammation
NLRP3 inflammasome
pyroptosis
Online Access:https://www.mdpi.com/2076-3425/12/8/976

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