ROS Induce Cardiomyocyte Apoptosis in Ascitic Broiler Chickens
It is believed that ascitic broilers die of right heart failure caused by pulmonary hypertension, but the underlying mechanisms of right heart failure are unknown. However, recent studies have shown that reactive oxygen species have the ability to damage heart cells. This study aimed to determine th...
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| Format: | Article |
| Language: | English |
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University of Agriculture, Faisalabad
2012-10-01
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| Series: | Pakistan Veterinary Journal |
| Subjects: | |
| Online Access: | http://pvj.com.pk/pdf-files/32_4/613-617.pdf |
| _version_ | 1811218216212496384 |
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| author | Zhaofang Xi§, Shijin Yang§, Dongyang Liu, Liming Wu, Xiaodong Liu, Jing Zhao and Dingzong Guo* |
| author_facet | Zhaofang Xi§, Shijin Yang§, Dongyang Liu, Liming Wu, Xiaodong Liu, Jing Zhao and Dingzong Guo* |
| author_sort | Zhaofang Xi§, Shijin Yang§, Dongyang Liu, Liming Wu, Xiaodong Liu, Jing Zhao and Dingzong Guo* |
| collection | DOAJ |
| description | It is believed that ascitic broilers die of right heart failure caused by pulmonary hypertension, but the underlying mechanisms of right heart failure are unknown. However, recent studies have shown that reactive oxygen species have the ability to damage heart cells. This study aimed to determine the changes of reactive oxygen species in serum and plasma, and the effect of this variation on myocardial cells during broiler ascites. We used hypoxia and a low-temperature method to induce broiler ascites in the fast-growing group. For controls, we treated a slow-growing group of broilers with 70% restricted feeding under the same circumstances as the fast-growing group. The results showed that hypoxia is a more effective and better way to induce broiler ascites than a low-temperature environment and high growth rate. In addition, reactive oxygen species levels were significantly increased in the fast-growing group compared with those in the slow-growing group. This significant increase in reactive oxygen species resulted in myocardial cell apoptosis in the fast-growing group. Our results suggest that cardiomyocyte apoptosis caused by increased reactive oxygen species levels of ascitic broilers is one of the most important reasons for causing heart failure. |
| first_indexed | 2024-04-12T07:06:19Z |
| format | Article |
| id | doaj.art-994a49a3f0134c0bbb9abdc243fa2b3e |
| institution | Directory Open Access Journal |
| issn | 0253-8318 |
| language | English |
| last_indexed | 2024-04-12T07:06:19Z |
| publishDate | 2012-10-01 |
| publisher | University of Agriculture, Faisalabad |
| record_format | Article |
| series | Pakistan Veterinary Journal |
| spelling | doaj.art-994a49a3f0134c0bbb9abdc243fa2b3e2022-12-22T03:42:47ZengUniversity of Agriculture, FaisalabadPakistan Veterinary Journal0253-83182012-10-01324613617ROS Induce Cardiomyocyte Apoptosis in Ascitic Broiler ChickensZhaofang Xi§, Shijin Yang§, Dongyang Liu, Liming Wu, Xiaodong Liu, Jing Zhao and Dingzong Guo*It is believed that ascitic broilers die of right heart failure caused by pulmonary hypertension, but the underlying mechanisms of right heart failure are unknown. However, recent studies have shown that reactive oxygen species have the ability to damage heart cells. This study aimed to determine the changes of reactive oxygen species in serum and plasma, and the effect of this variation on myocardial cells during broiler ascites. We used hypoxia and a low-temperature method to induce broiler ascites in the fast-growing group. For controls, we treated a slow-growing group of broilers with 70% restricted feeding under the same circumstances as the fast-growing group. The results showed that hypoxia is a more effective and better way to induce broiler ascites than a low-temperature environment and high growth rate. In addition, reactive oxygen species levels were significantly increased in the fast-growing group compared with those in the slow-growing group. This significant increase in reactive oxygen species resulted in myocardial cell apoptosis in the fast-growing group. Our results suggest that cardiomyocyte apoptosis caused by increased reactive oxygen species levels of ascitic broilers is one of the most important reasons for causing heart failure.http://pvj.com.pk/pdf-files/32_4/613-617.pdfApoptosisAscitesLipid peroxidationReactive oxygen species (ROS) |
| spellingShingle | Zhaofang Xi§, Shijin Yang§, Dongyang Liu, Liming Wu, Xiaodong Liu, Jing Zhao and Dingzong Guo* ROS Induce Cardiomyocyte Apoptosis in Ascitic Broiler Chickens Pakistan Veterinary Journal Apoptosis Ascites Lipid peroxidation Reactive oxygen species (ROS) |
| title | ROS Induce Cardiomyocyte Apoptosis in Ascitic Broiler Chickens |
| title_full | ROS Induce Cardiomyocyte Apoptosis in Ascitic Broiler Chickens |
| title_fullStr | ROS Induce Cardiomyocyte Apoptosis in Ascitic Broiler Chickens |
| title_full_unstemmed | ROS Induce Cardiomyocyte Apoptosis in Ascitic Broiler Chickens |
| title_short | ROS Induce Cardiomyocyte Apoptosis in Ascitic Broiler Chickens |
| title_sort | ros induce cardiomyocyte apoptosis in ascitic broiler chickens |
| topic | Apoptosis Ascites Lipid peroxidation Reactive oxygen species (ROS) |
| url | http://pvj.com.pk/pdf-files/32_4/613-617.pdf |
| work_keys_str_mv | AT zhaofangxishijinyangdongyangliulimingwuxiaodongliujingzhaoanddingzongguo rosinducecardiomyocyteapoptosisinasciticbroilerchickens |