The replication machinery of LUCA: common origin of DNA replication and transcription
Abstract Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Biology |
| Online Access: | http://link.springer.com/article/10.1186/s12915-020-00800-9 |
| _version_ | 1828768662495952896 |
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| author | Eugene V. Koonin Mart Krupovic Sonoko Ishino Yoshizumi Ishino |
| author_facet | Eugene V. Koonin Mart Krupovic Sonoko Ishino Yoshizumi Ishino |
| author_sort | Eugene V. Koonin |
| collection | DOAJ |
| description | Abstract Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA replication. The replicative DNAP of the Last Universal Cellular Ancestor (LUCA) would be the ancestor of the archaeal PolD. |
| first_indexed | 2024-12-11T13:33:53Z |
| format | Article |
| id | doaj.art-994cffbcb26e4eb7bd419f056281c4ff |
| institution | Directory Open Access Journal |
| issn | 1741-7007 |
| language | English |
| last_indexed | 2024-12-11T13:33:53Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj.art-994cffbcb26e4eb7bd419f056281c4ff2022-12-22T01:05:09ZengBMCBMC Biology1741-70072020-06-011811810.1186/s12915-020-00800-9The replication machinery of LUCA: common origin of DNA replication and transcriptionEugene V. Koonin0Mart Krupovic1Sonoko Ishino2Yoshizumi Ishino3National Center for Biotechnology Information, National Library of Medicine, National Institutes of HealthArchaeal Virology Unit, Institut PasteurDepartment of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu UniversityDepartment of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu UniversityAbstract Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA replication. The replicative DNAP of the Last Universal Cellular Ancestor (LUCA) would be the ancestor of the archaeal PolD.http://link.springer.com/article/10.1186/s12915-020-00800-9 |
| spellingShingle | Eugene V. Koonin Mart Krupovic Sonoko Ishino Yoshizumi Ishino The replication machinery of LUCA: common origin of DNA replication and transcription BMC Biology |
| title | The replication machinery of LUCA: common origin of DNA replication and transcription |
| title_full | The replication machinery of LUCA: common origin of DNA replication and transcription |
| title_fullStr | The replication machinery of LUCA: common origin of DNA replication and transcription |
| title_full_unstemmed | The replication machinery of LUCA: common origin of DNA replication and transcription |
| title_short | The replication machinery of LUCA: common origin of DNA replication and transcription |
| title_sort | replication machinery of luca common origin of dna replication and transcription |
| url | http://link.springer.com/article/10.1186/s12915-020-00800-9 |
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