Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic
Chronic arsenic exposure via drinking water is associated with diabetes in human pop-ulations throughout the world. Arsenic is believed to exert its diabetogenic effects via multiple mechanisms, including alterations to insulin secretion and insulin sensitivity. In the past, acute arsenicosis has be...
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MDPI AG
2021-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/8/2894 |
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| author | Christopher M. Carmean Mizuho Mimoto Michael Landeche Daniel Ruiz Bijoy Chellan Lidan Zhao Margaret C. Schulz Alexandra M. Dumitrescu Robert M. Sargis |
| author_facet | Christopher M. Carmean Mizuho Mimoto Michael Landeche Daniel Ruiz Bijoy Chellan Lidan Zhao Margaret C. Schulz Alexandra M. Dumitrescu Robert M. Sargis |
| author_sort | Christopher M. Carmean |
| collection | DOAJ |
| description | Chronic arsenic exposure via drinking water is associated with diabetes in human pop-ulations throughout the world. Arsenic is believed to exert its diabetogenic effects via multiple mechanisms, including alterations to insulin secretion and insulin sensitivity. In the past, acute arsenicosis has been thought to be partially treatable with selenium supplementation, though a potential interaction between selenium and arsenic had not been evaluated under longer-term exposure models. The purpose of the present study was to explore whether selenium status may augment arsenic’s effects during chronic arsenic exposure. To test this possibility, mice were exposed to arsenic in their drinking water and provided ad libitum access to either a diet replete with selenium (Control) or deficient in selenium (SelD). Arsenic significantly improved glucose tolerance and decreased insulin secretion and β-cell function in vivo. Dietary selenium deficiency resulted in similar effects on glucose tolerance and insulin secretion, with significant interactions between arsenic and dietary conditions in select insulin-related parameters. The findings of this study highlight the complexity of arsenic’s metabolic effects and suggest that selenium deficiency may interact with arsenic exposure on β-cell-related physiological parameters. |
| first_indexed | 2024-03-10T08:30:23Z |
| format | Article |
| id | doaj.art-994eae19d3dd4743858831bdce0960d0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T08:30:23Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-994eae19d3dd4743858831bdce0960d02023-11-22T09:07:43ZengMDPI AGNutrients2072-66432021-08-01138289410.3390/nu13082894Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of ArsenicChristopher M. Carmean0Mizuho Mimoto1Michael Landeche2Daniel Ruiz3Bijoy Chellan4Lidan Zhao5Margaret C. Schulz6Alexandra M. Dumitrescu7Robert M. Sargis8Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USASection of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, IL 60637, USADivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USACommittee on Molecular Metabolism and Nutrition, University of Chicago, Chicago, IL 60637, USADivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USASection of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, IL 60637, USADivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USAChronic arsenic exposure via drinking water is associated with diabetes in human pop-ulations throughout the world. Arsenic is believed to exert its diabetogenic effects via multiple mechanisms, including alterations to insulin secretion and insulin sensitivity. In the past, acute arsenicosis has been thought to be partially treatable with selenium supplementation, though a potential interaction between selenium and arsenic had not been evaluated under longer-term exposure models. The purpose of the present study was to explore whether selenium status may augment arsenic’s effects during chronic arsenic exposure. To test this possibility, mice were exposed to arsenic in their drinking water and provided ad libitum access to either a diet replete with selenium (Control) or deficient in selenium (SelD). Arsenic significantly improved glucose tolerance and decreased insulin secretion and β-cell function in vivo. Dietary selenium deficiency resulted in similar effects on glucose tolerance and insulin secretion, with significant interactions between arsenic and dietary conditions in select insulin-related parameters. The findings of this study highlight the complexity of arsenic’s metabolic effects and suggest that selenium deficiency may interact with arsenic exposure on β-cell-related physiological parameters.https://www.mdpi.com/2072-6643/13/8/2894seleniumarsenicnutritiondietary interventioninsulin secretionendocrine-disrupting chemicals |
| spellingShingle | Christopher M. Carmean Mizuho Mimoto Michael Landeche Daniel Ruiz Bijoy Chellan Lidan Zhao Margaret C. Schulz Alexandra M. Dumitrescu Robert M. Sargis Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic Nutrients selenium arsenic nutrition dietary intervention insulin secretion endocrine-disrupting chemicals |
| title | Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic |
| title_full | Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic |
| title_fullStr | Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic |
| title_full_unstemmed | Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic |
| title_short | Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic |
| title_sort | dietary selenium deficiency partially mimics the metabolic effects of arsenic |
| topic | selenium arsenic nutrition dietary intervention insulin secretion endocrine-disrupting chemicals |
| url | https://www.mdpi.com/2072-6643/13/8/2894 |
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