Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain

Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain

The discovery of meningeal lymphatic vessels that drain the CNS has prompted new insights into how immune responses develop in the brain. In this study, we examined how T cell responses against CNS-derived antigen develop in the context of infection. We found that meningeal lymphatic drainage promot...

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Bibliographic Details
Main Authors: Michael A Kovacs, Maureen N Cowan, Isaac W Babcock, Lydia A Sibley, Katherine Still, Samantha J Batista, Sydney A Labuzan, Ish Sethi, Tajie H Harris
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
Toxoplasma gondii
neuroimmunology
lymphatics
T cells
Online Access:https://elifesciences.org/articles/80775

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