DBS in the baso-lateral amygdala improves symptoms of autism and related self-injurious behaviourA case report and hypothesis on the pathogenesis of the disorder
We treated a thirteen year old boy for life-threatening self-injurious behavior (SIB) and severe Kanner’s autism with Deep Brain Stimulation (DBS) in the amygdaloid complex as well as in the supra-amygdaloid projection system. Two DBS-electrodes were placed in both structures of each hemisphere. The...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-01-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00341/full |
| _version_ | 1811341176048975872 |
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| author | Volker eSturm Oliver eFricke Christian P. Buehrle Doris eLenartz Mohammad eMaarouf Harald eTreuer Jürgen K. Mai Gerd eLehmkuhl |
| author_facet | Volker eSturm Oliver eFricke Christian P. Buehrle Doris eLenartz Mohammad eMaarouf Harald eTreuer Jürgen K. Mai Gerd eLehmkuhl |
| author_sort | Volker eSturm |
| collection | DOAJ |
| description | We treated a thirteen year old boy for life-threatening self-injurious behavior (SIB) and severe Kanner’s autism with Deep Brain Stimulation (DBS) in the amygdaloid complex as well as in the supra-amygdaloid projection system. Two DBS-electrodes were placed in both structures of each hemisphere. The stimulation contacts targeted the paralaminar, the basolateral, the central amygdala as well as the supra-amygdaloid projection system. DBS was applied to each of these structures, but only stimulation of the baso-lateral part proved effective in improving SIB and core symptoms of the autism spectrum in the emotional, social and even cognitive domains over a follow up of now 24 months. These results, which have been gained for the first time in a patient, support hypotheses, according to which the amygdala may be pivotal in the pathogeneses of autism and point to the special relevance of the baso-lateral part. |
| first_indexed | 2024-04-13T18:53:47Z |
| format | Article |
| id | doaj.art-994f68bfd8684fb7a0ac4c3d4a4b4850 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-13T18:53:47Z |
| publishDate | 2013-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-994f68bfd8684fb7a0ac4c3d4a4b48502022-12-22T02:34:20ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612013-01-01610.3389/fnhum.2012.0034118459DBS in the baso-lateral amygdala improves symptoms of autism and related self-injurious behaviourA case report and hypothesis on the pathogenesis of the disorderVolker eSturm0Oliver eFricke1Christian P. Buehrle2Doris eLenartz3Mohammad eMaarouf4Harald eTreuer5Jürgen K. Mai6Gerd eLehmkuhl7University of CologneUniversity of CologneUniversity of CologneUniversity of CologneUniversity of CologneUniversity of CologneUniversity of DüsseldorfUniversity of CologneWe treated a thirteen year old boy for life-threatening self-injurious behavior (SIB) and severe Kanner’s autism with Deep Brain Stimulation (DBS) in the amygdaloid complex as well as in the supra-amygdaloid projection system. Two DBS-electrodes were placed in both structures of each hemisphere. The stimulation contacts targeted the paralaminar, the basolateral, the central amygdala as well as the supra-amygdaloid projection system. DBS was applied to each of these structures, but only stimulation of the baso-lateral part proved effective in improving SIB and core symptoms of the autism spectrum in the emotional, social and even cognitive domains over a follow up of now 24 months. These results, which have been gained for the first time in a patient, support hypotheses, according to which the amygdala may be pivotal in the pathogeneses of autism and point to the special relevance of the baso-lateral part.http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00341/fullAmygdalaDeep Brain Stimulationautismcase reporthyperexcitabilitySelf-injurious Behaviour |
| spellingShingle | Volker eSturm Oliver eFricke Christian P. Buehrle Doris eLenartz Mohammad eMaarouf Harald eTreuer Jürgen K. Mai Gerd eLehmkuhl DBS in the baso-lateral amygdala improves symptoms of autism and related self-injurious behaviourA case report and hypothesis on the pathogenesis of the disorder Frontiers in Human Neuroscience Amygdala Deep Brain Stimulation autism case report hyperexcitability Self-injurious Behaviour |
| title | DBS in the baso-lateral amygdala improves symptoms of autism and related self-injurious behaviourA case report and hypothesis on the pathogenesis of the disorder |
| title_full | DBS in the baso-lateral amygdala improves symptoms of autism and related self-injurious behaviourA case report and hypothesis on the pathogenesis of the disorder |
| title_fullStr | DBS in the baso-lateral amygdala improves symptoms of autism and related self-injurious behaviourA case report and hypothesis on the pathogenesis of the disorder |
| title_full_unstemmed | DBS in the baso-lateral amygdala improves symptoms of autism and related self-injurious behaviourA case report and hypothesis on the pathogenesis of the disorder |
| title_short | DBS in the baso-lateral amygdala improves symptoms of autism and related self-injurious behaviourA case report and hypothesis on the pathogenesis of the disorder |
| title_sort | dbs in the baso lateral amygdala improves symptoms of autism and related self injurious behavioura case report and hypothesis on the pathogenesis of the disorder |
| topic | Amygdala Deep Brain Stimulation autism case report hyperexcitability Self-injurious Behaviour |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2012.00341/full |
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