Frequency of HTLV-1 seroconversion between pregnancies in Nagasaki, Japan, 2011–2018
BackgroundHuman T-cell leukemia virus type-1 (HTLV-1) is transmitted vertically from an infected mother to her child via breastfeeding during infancy or horizontally via sexual contact. However, little information is available on the HTLV-1 seroconversion rate in pregnant mothers and the impact of n...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1036955/full |
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| author | Nahoko Komatsu Masako Iwanaga Yuri Hasegawa Shoko Miura Naoki Fuchi Hiroyuki Moriuchi Katsunori Yanagihara Kiyonori Miura |
| author_facet | Nahoko Komatsu Masako Iwanaga Yuri Hasegawa Shoko Miura Naoki Fuchi Hiroyuki Moriuchi Katsunori Yanagihara Kiyonori Miura |
| author_sort | Nahoko Komatsu |
| collection | DOAJ |
| description | BackgroundHuman T-cell leukemia virus type-1 (HTLV-1) is transmitted vertically from an infected mother to her child via breastfeeding during infancy or horizontally via sexual contact. However, little information is available on the HTLV-1 seroconversion rate in pregnant mothers and the impact of new HTLV-1 infection on mothers and babies during the perinatal period.MethodsFrom the database of a prefecture-wide antenatal adult T-cell leukemia prevention program in Nagasaki, Japan, we extracted data on 57,323 pregnant women who were screened for anti-HTLV-1 antibody during 2011–2018. Data on the 16,863 subjects whose HTLV-1 proviral load (PVL) was measured more than twice were included in our analyses.ResultsIn total, 133 (0.79%) pregnant women were HTLV-1-positive during their first pregnancy and nine (0.05%) seroconverted before or during subsequent pregnancies (between pregnancies). The median PVL (per 100 peripheral blood mononuclear cells) was significantly lower in the seroconverted mothers (0.10%) than in the initially seropositive mothers (0.15%). A repeated measures correlation analysis for the individual PVLs of the HTLV-1-positive pregnant women showed that PVL increased with parity number (rrm = 0.25) with no perinatal problems.ConclusionThe HTLV-1 seroconversion rate between pregnancies was 0.05%, and their HTLV-1 PVL increased annually but no perinatal problems were noted. |
| first_indexed | 2024-04-11T06:44:41Z |
| format | Article |
| id | doaj.art-994f728fceb04000987b3e89fb1280b8 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-11T06:44:41Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-994f728fceb04000987b3e89fb1280b82022-12-22T04:39:23ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-11-011310.3389/fmicb.2022.10369551036955Frequency of HTLV-1 seroconversion between pregnancies in Nagasaki, Japan, 2011–2018Nahoko Komatsu0Masako Iwanaga1Yuri Hasegawa2Shoko Miura3Naoki Fuchi4Hiroyuki Moriuchi5Katsunori Yanagihara6Kiyonori Miura7Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Clinical Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanBackgroundHuman T-cell leukemia virus type-1 (HTLV-1) is transmitted vertically from an infected mother to her child via breastfeeding during infancy or horizontally via sexual contact. However, little information is available on the HTLV-1 seroconversion rate in pregnant mothers and the impact of new HTLV-1 infection on mothers and babies during the perinatal period.MethodsFrom the database of a prefecture-wide antenatal adult T-cell leukemia prevention program in Nagasaki, Japan, we extracted data on 57,323 pregnant women who were screened for anti-HTLV-1 antibody during 2011–2018. Data on the 16,863 subjects whose HTLV-1 proviral load (PVL) was measured more than twice were included in our analyses.ResultsIn total, 133 (0.79%) pregnant women were HTLV-1-positive during their first pregnancy and nine (0.05%) seroconverted before or during subsequent pregnancies (between pregnancies). The median PVL (per 100 peripheral blood mononuclear cells) was significantly lower in the seroconverted mothers (0.10%) than in the initially seropositive mothers (0.15%). A repeated measures correlation analysis for the individual PVLs of the HTLV-1-positive pregnant women showed that PVL increased with parity number (rrm = 0.25) with no perinatal problems.ConclusionThe HTLV-1 seroconversion rate between pregnancies was 0.05%, and their HTLV-1 PVL increased annually but no perinatal problems were noted.https://www.frontiersin.org/articles/10.3389/fmicb.2022.1036955/fullHTLV-1pregnant womancarrierscreening testseroconversionhorizontal transmission |
| spellingShingle | Nahoko Komatsu Masako Iwanaga Yuri Hasegawa Shoko Miura Naoki Fuchi Hiroyuki Moriuchi Katsunori Yanagihara Kiyonori Miura Frequency of HTLV-1 seroconversion between pregnancies in Nagasaki, Japan, 2011–2018 Frontiers in Microbiology HTLV-1 pregnant woman carrier screening test seroconversion horizontal transmission |
| title | Frequency of HTLV-1 seroconversion between pregnancies in Nagasaki, Japan, 2011–2018 |
| title_full | Frequency of HTLV-1 seroconversion between pregnancies in Nagasaki, Japan, 2011–2018 |
| title_fullStr | Frequency of HTLV-1 seroconversion between pregnancies in Nagasaki, Japan, 2011–2018 |
| title_full_unstemmed | Frequency of HTLV-1 seroconversion between pregnancies in Nagasaki, Japan, 2011–2018 |
| title_short | Frequency of HTLV-1 seroconversion between pregnancies in Nagasaki, Japan, 2011–2018 |
| title_sort | frequency of htlv 1 seroconversion between pregnancies in nagasaki japan 2011 2018 |
| topic | HTLV-1 pregnant woman carrier screening test seroconversion horizontal transmission |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1036955/full |
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