High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs
Major depressive disorder is a common diagnosis associated with a high burden of disease that has proven to be highly heterogeneous and unreliable. Treatments currently available demonstrate limited efficacy and effectiveness. New drug development is urgently required but is likely to be hindered by...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2015-10-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S205647240000106X/type/journal_article |
| _version_ | 1811157106724700160 |
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| author | Samuel M. Lieblich David J. Castle Christos Pantelis Malcolm Hopwood Allan Hunter Young Ian P. Everall |
| author_facet | Samuel M. Lieblich David J. Castle Christos Pantelis Malcolm Hopwood Allan Hunter Young Ian P. Everall |
| author_sort | Samuel M. Lieblich |
| collection | DOAJ |
| description | Major depressive disorder is a common diagnosis associated with a high burden of disease that has proven to be highly heterogeneous and unreliable. Treatments currently available demonstrate limited efficacy and effectiveness. New drug development is urgently required but is likely to be hindered by diagnostic limitations. |
| first_indexed | 2024-04-10T05:01:32Z |
| format | Article |
| id | doaj.art-99513aea2c914d3fa697f07e92b50ca7 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T05:01:32Z |
| publishDate | 2015-10-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-99513aea2c914d3fa697f07e92b50ca72023-03-09T12:28:35ZengCambridge University PressBJPsych Open2056-47242015-10-011e5e710.1192/bjpo.bp.115.000786High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugsSamuel M. Lieblich0David J. Castle1Christos Pantelis2Malcolm Hopwood3Allan Hunter Young4Ian P. Everall5Department of Psychiatry, University of Melbourne, Melbourne, AustraliaSt Vincent's Hospital Melbourne and The University of Melbourne and Faculty of Health Sciences, Australian Catholic University, Melbourne, AustraliaMelbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health and Florey Institute for Neuroscience & Mental Health, Melbourne, Australia, and Bedfordshire Centre For Mental Health Research in Association with the University of Cambridge, UKProfessorial Psychiatry Unit, Albert Road Clinic, and University of Melbourne, Melbourne, AustraliaCentre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UKDepartment of Psychiatry, University of Melbourne, Melbourne, AustraliaMajor depressive disorder is a common diagnosis associated with a high burden of disease that has proven to be highly heterogeneous and unreliable. Treatments currently available demonstrate limited efficacy and effectiveness. New drug development is urgently required but is likely to be hindered by diagnostic limitations.https://www.cambridge.org/core/product/identifier/S205647240000106X/type/journal_article |
| spellingShingle | Samuel M. Lieblich David J. Castle Christos Pantelis Malcolm Hopwood Allan Hunter Young Ian P. Everall High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs BJPsych Open |
| title | High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs |
| title_full | High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs |
| title_fullStr | High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs |
| title_full_unstemmed | High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs |
| title_short | High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs |
| title_sort | high heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs |
| url | https://www.cambridge.org/core/product/identifier/S205647240000106X/type/journal_article |
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