PFAS Biotransformation Pathways: A Species Comparison Study
Limited availability of fish metabolic pathways for PFAS may lead to risk assessments with inherent uncertainties based only upon the parent chemical or the assumption that the biodegradation or mammalian metabolism map data will serve as an adequate surrogate. A rapid and transparent process, utili...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/11/1/74 |
| _version_ | 1797436765526556672 |
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| author | Richard C. Kolanczyk Megan R. Saley Jose A. Serrano Sara M. Daley Mark A. Tapper |
| author_facet | Richard C. Kolanczyk Megan R. Saley Jose A. Serrano Sara M. Daley Mark A. Tapper |
| author_sort | Richard C. Kolanczyk |
| collection | DOAJ |
| description | Limited availability of fish metabolic pathways for PFAS may lead to risk assessments with inherent uncertainties based only upon the parent chemical or the assumption that the biodegradation or mammalian metabolism map data will serve as an adequate surrogate. A rapid and transparent process, utilizing a recently created database of systematically collected information for fish, mammals, poultry, plant, earthworm, sediment, sludge, bacteria, and fungus using data evaluation tools in the previously described metabolism pathway software system MetaPath, is presented. The fish metabolism maps for 10 PFAS, heptadecafluorooctyl(tridecafluorohexyl)phosphinic acid (C6/C8 PFPiA), bis(perfluorooctyl)phosphinic acid (C8/C8 PFPiA), 2-[(6-chloro-1,1,2,2,3,3,4,4,5,5,6,6-dodecafluorohexyl)oxy]-1,1,2,2-tetrafluoroethanesulfonic acid (6:2 Cl-PFESA), <i>N</i>-Ethylperfluorooctane-1-sulfonamide (Sulfuramid; N-EtFOSA), <i>N</i>-Ethyl Perfluorooctane Sulfonamido Ethanol phosphate diester (SAmPAP), Perfluorooctanesulfonamide (FOSA), 8:2 Fluorotelomer phosphate diester (8:2 diPAP), 8:2 fluorotelomer alcohol (8:2 FTOH), 10:2 fluorotelomer alcohol (10:2 FTOH), and 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB), were compared across multiple species and systems. The approach demonstrates how comparisons of metabolic maps across species are aided by considering the sample matrix in which metabolites were quantified for each species, differences in analytical methods used to identify metabolites in each study, and the relative amounts of metabolites quantified. Overall, the pathways appear to be well conserved across species and systems. For PFAS lacking a fish metabolism study, a composite map consisting of all available maps would serve as the best basis for metabolite prediction. This emphasizes the importance and utility of collating metabolism into a searchable database such as that created in this effort. |
| first_indexed | 2024-03-09T11:06:20Z |
| format | Article |
| id | doaj.art-9951af574e634294870538311ea92b51 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T11:06:20Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-9951af574e634294870538311ea92b512023-12-01T00:56:03ZengMDPI AGToxics2305-63042023-01-011117410.3390/toxics11010074PFAS Biotransformation Pathways: A Species Comparison StudyRichard C. Kolanczyk0Megan R. Saley1Jose A. Serrano2Sara M. Daley3Mark A. Tapper4Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, 6201 Congdon Blvd., Duluth, MN 55804, USAOak Ridge Institute for Science and Education, Great Lakes Toxicology and Ecology Division, 6201 Congdon Blvd., Duluth, MN 55804, USAGreat Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, 6201 Congdon Blvd., Duluth, MN 55804, USAOak Ridge Institute for Science and Education, Great Lakes Toxicology and Ecology Division, 6201 Congdon Blvd., Duluth, MN 55804, USAGreat Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, 6201 Congdon Blvd., Duluth, MN 55804, USALimited availability of fish metabolic pathways for PFAS may lead to risk assessments with inherent uncertainties based only upon the parent chemical or the assumption that the biodegradation or mammalian metabolism map data will serve as an adequate surrogate. A rapid and transparent process, utilizing a recently created database of systematically collected information for fish, mammals, poultry, plant, earthworm, sediment, sludge, bacteria, and fungus using data evaluation tools in the previously described metabolism pathway software system MetaPath, is presented. The fish metabolism maps for 10 PFAS, heptadecafluorooctyl(tridecafluorohexyl)phosphinic acid (C6/C8 PFPiA), bis(perfluorooctyl)phosphinic acid (C8/C8 PFPiA), 2-[(6-chloro-1,1,2,2,3,3,4,4,5,5,6,6-dodecafluorohexyl)oxy]-1,1,2,2-tetrafluoroethanesulfonic acid (6:2 Cl-PFESA), <i>N</i>-Ethylperfluorooctane-1-sulfonamide (Sulfuramid; N-EtFOSA), <i>N</i>-Ethyl Perfluorooctane Sulfonamido Ethanol phosphate diester (SAmPAP), Perfluorooctanesulfonamide (FOSA), 8:2 Fluorotelomer phosphate diester (8:2 diPAP), 8:2 fluorotelomer alcohol (8:2 FTOH), 10:2 fluorotelomer alcohol (10:2 FTOH), and 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB), were compared across multiple species and systems. The approach demonstrates how comparisons of metabolic maps across species are aided by considering the sample matrix in which metabolites were quantified for each species, differences in analytical methods used to identify metabolites in each study, and the relative amounts of metabolites quantified. Overall, the pathways appear to be well conserved across species and systems. For PFAS lacking a fish metabolism study, a composite map consisting of all available maps would serve as the best basis for metabolite prediction. This emphasizes the importance and utility of collating metabolism into a searchable database such as that created in this effort.https://www.mdpi.com/2305-6304/11/1/74PFASbiotransformationmetabolismfishbiodegradationpathway |
| spellingShingle | Richard C. Kolanczyk Megan R. Saley Jose A. Serrano Sara M. Daley Mark A. Tapper PFAS Biotransformation Pathways: A Species Comparison Study Toxics PFAS biotransformation metabolism fish biodegradation pathway |
| title | PFAS Biotransformation Pathways: A Species Comparison Study |
| title_full | PFAS Biotransformation Pathways: A Species Comparison Study |
| title_fullStr | PFAS Biotransformation Pathways: A Species Comparison Study |
| title_full_unstemmed | PFAS Biotransformation Pathways: A Species Comparison Study |
| title_short | PFAS Biotransformation Pathways: A Species Comparison Study |
| title_sort | pfas biotransformation pathways a species comparison study |
| topic | PFAS biotransformation metabolism fish biodegradation pathway |
| url | https://www.mdpi.com/2305-6304/11/1/74 |
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