Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in mice
Parsley, a common vegetable, is widely used as a condiment because its flavor. However, its biological functionality remains largely ignored. In this study, the antioxidant activity-guided separation method was used to obtain four characteristic 7-O-flavonoid glycosides from parsley. An excessive fa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622000330 |
| _version_ | 1828143303905771520 |
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| author | Yu Wang Yubiao Zhang Mingxiao Hou Wenfeng Han |
| author_facet | Yu Wang Yubiao Zhang Mingxiao Hou Wenfeng Han |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | Parsley, a common vegetable, is widely used as a condiment because its flavor. However, its biological functionality remains largely ignored. In this study, the antioxidant activity-guided separation method was used to obtain four characteristic 7-O-flavonoid glycosides from parsley. An excessive fatigue mouse model was used to evaluate the anti-fatigue effects of the different parsley extracts. The results showed that parsley flavonoids could significantly improve fatigue related physiological indicators and morphology of the gastrocnemius muscle. Western blotting indicated that parsley flavonoids could regulate oxidative stress and exert an anti-fatigue effect by regulating the Keap1/Nrf2 and AMPK/PGC-1α pathways. Furthermore, the intake of flavonoids stimulated the enrichment of probiotics and short chain fatty acid producing microbiota, which likely participate in the body's energy metabolism and regulate fatigue. The present findings expand the conventional understanding of parsley as a seasoning food, proving that it has the potential for further development as a functional food. |
| first_indexed | 2024-04-11T19:55:01Z |
| format | Article |
| id | doaj.art-9951e05dbd4f405eb43c5b158ce8a05a |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-11T19:55:01Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-9951e05dbd4f405eb43c5b158ce8a05a2022-12-22T04:06:12ZengElsevierJournal of Functional Foods1756-46462022-02-0189104963Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in miceYu Wang0Yubiao Zhang1Mingxiao Hou2Wenfeng Han3College of Food Science, Shenyang Agricultural University, Liaoning Province, Shenyang, Liaoning 110866, China; Orthopedics Department of General Hospital of Northern Theatre command, No. 83 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, ChinaCollege of Food Science, Shenyang Agricultural University, Liaoning Province, Shenyang, Liaoning 110866, ChinaCollege of Food Science, Shenyang Agricultural University, Liaoning Province, Shenyang, Liaoning 110866, China; General Hospital of Northern Theatre command, No. 83 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, China; Corresponding authors at: College of Food Science, Shenyang Agricultural University, Liaoning Province, Shenyang, Liaoning 110866, China. General Hospital of Northern Theatre command, No. 83 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, China.General Hospital of Northern Theatre command, No. 83 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, China; Corresponding authors at: College of Food Science, Shenyang Agricultural University, Liaoning Province, Shenyang, Liaoning 110866, China. General Hospital of Northern Theatre command, No. 83 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, China.Parsley, a common vegetable, is widely used as a condiment because its flavor. However, its biological functionality remains largely ignored. In this study, the antioxidant activity-guided separation method was used to obtain four characteristic 7-O-flavonoid glycosides from parsley. An excessive fatigue mouse model was used to evaluate the anti-fatigue effects of the different parsley extracts. The results showed that parsley flavonoids could significantly improve fatigue related physiological indicators and morphology of the gastrocnemius muscle. Western blotting indicated that parsley flavonoids could regulate oxidative stress and exert an anti-fatigue effect by regulating the Keap1/Nrf2 and AMPK/PGC-1α pathways. Furthermore, the intake of flavonoids stimulated the enrichment of probiotics and short chain fatty acid producing microbiota, which likely participate in the body's energy metabolism and regulate fatigue. The present findings expand the conventional understanding of parsley as a seasoning food, proving that it has the potential for further development as a functional food.http://www.sciencedirect.com/science/article/pii/S1756464622000330ParsleyFlavonoidsAnti-fatigueOxidative stressGut microbiota |
| spellingShingle | Yu Wang Yubiao Zhang Mingxiao Hou Wenfeng Han Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in mice Journal of Functional Foods Parsley Flavonoids Anti-fatigue Oxidative stress Gut microbiota |
| title | Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in mice |
| title_full | Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in mice |
| title_fullStr | Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in mice |
| title_full_unstemmed | Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in mice |
| title_short | Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in mice |
| title_sort | anti fatigue activity of parsley petroselinum crispum flavonoids via regulation of oxidative stress and gut microbiota in mice |
| topic | Parsley Flavonoids Anti-fatigue Oxidative stress Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622000330 |
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