The Deubiquitinase USP13 Maintains Cancer Cell Stemness by Promoting FASN Stability in Small Cell Lung Cancer

The Deubiquitinase USP13 Maintains Cancer Cell Stemness by Promoting FASN Stability in Small Cell Lung Cancer

USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. However, the functional role of USP13 in small cell lung cancer (SCLC) remains largely unclear. In this study, we found that the deubiquitinase USP13 is highly expressed in SCLC tumor samples and...

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Bibliographic Details
Main Authors: Juhong Wang, Weihao Lin, Renda Li, Hong Cheng, Sijin Sun, Fei Shao, Yannan Yang, Lin Zhang, Xiaoli Feng, Shugeng Gao, Yibo Gao, Jie He
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
USP13
cancer stem cells
FASN
ubiquitylation
lipogenesis
TVB-2640
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.899987/full

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