Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study
ObjectiveLactobacillus paragasseri SBT2055 (LG2055) has been reported to show immunostimulating effects. This study aimed to investigate the effects of LG2055 on the subjective symptoms of the physical condition in healthy adults.Materials and methodsIn this randomized, double-blind, placebo-control...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1063584/full |
| _version_ | 1811206003831603200 |
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| author | Eiji Kobatake Yoshitaka Iwama Toshinobu Arai Nobuhiko Shioya Mai Kise Toshihide Kabuki |
| author_facet | Eiji Kobatake Yoshitaka Iwama Toshinobu Arai Nobuhiko Shioya Mai Kise Toshihide Kabuki |
| author_sort | Eiji Kobatake |
| collection | DOAJ |
| description | ObjectiveLactobacillus paragasseri SBT2055 (LG2055) has been reported to show immunostimulating effects. This study aimed to investigate the effects of LG2055 on the subjective symptoms of the physical condition in healthy adults.Materials and methodsIn this randomized, double-blind, placebo-controlled, parallel-group comparative study, Japanese individuals aged 20–64 years were recruited. A total of 200 participants were randomly divided into two groups by an independent controller (LG2055 and placebo groups; 100 participants per group). Drinkable yogurts containing LG2055 or lacking LG2055 (placebo) were used as test samples. The participants ingested one bottle of the test sample once a day for 12 weeks. A daily physical health questionnaire survey (about common cold symptoms) was performed as the primary outcome, and immunological and oxidative stress markers in saliva and serum were evaluated as secondary outcomes.ResultsIn total, 198 participants completed the scheduled intake of the test samples, and five participants were excluded from the final analysis. Consequently, 193 participants (LG2055 group, n = 97; placebo group, n = 96) in the Per-Protocol Set were included in the efficacy analysis. The cumulative days of each symptom were evaluated, and the LG2055 group showed a significantly higher ratio of “without symptom” in runny nose, plugged nose, sneezing, sore throat, hoarseness, cough, headache, feeling tired, and fever than the placebo group, indicating that the incidence rates of common cold symptoms were lower in the LG2055 group. Additionally, changes in the salivary secretory IgA levels were significantly higher, and the serum derivatives of reactive oxygen metabolites levels were significantly lower in the LG2055 group.ConclusionOur study revealed that intake of LG2055 decreased common cold symptoms and improved immune parameters in healthy adults. This suggests that LG2055 contributes to the maintenance of physical conditions by improving the host immune system.Clinical trial registration[https://www.umin.ac.jp/ctr/index.htm], identifier [UMIN000045901]. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T03:40:07Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-9953b73f40ff40bcb9ddd20d8f47123d2022-12-22T03:49:18ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-12-01910.3389/fnut.2022.10635841063584Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative studyEiji Kobatake0Yoshitaka Iwama1Toshinobu Arai2Nobuhiko Shioya3Mai Kise4Toshihide Kabuki5Milk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., Saitama, JapanNihonbashi Cardiology Clinic, Tokyo, JapanResearch and Development Planning Department, MEGMILK SNOW BRAND Co., Ltd., Tokyo, JapanKSO Corporation, Tokyo, JapanProducts Development Department, MEGMILK SNOW BRAND Co., Ltd., Saitama, JapanMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., Saitama, JapanObjectiveLactobacillus paragasseri SBT2055 (LG2055) has been reported to show immunostimulating effects. This study aimed to investigate the effects of LG2055 on the subjective symptoms of the physical condition in healthy adults.Materials and methodsIn this randomized, double-blind, placebo-controlled, parallel-group comparative study, Japanese individuals aged 20–64 years were recruited. A total of 200 participants were randomly divided into two groups by an independent controller (LG2055 and placebo groups; 100 participants per group). Drinkable yogurts containing LG2055 or lacking LG2055 (placebo) were used as test samples. The participants ingested one bottle of the test sample once a day for 12 weeks. A daily physical health questionnaire survey (about common cold symptoms) was performed as the primary outcome, and immunological and oxidative stress markers in saliva and serum were evaluated as secondary outcomes.ResultsIn total, 198 participants completed the scheduled intake of the test samples, and five participants were excluded from the final analysis. Consequently, 193 participants (LG2055 group, n = 97; placebo group, n = 96) in the Per-Protocol Set were included in the efficacy analysis. The cumulative days of each symptom were evaluated, and the LG2055 group showed a significantly higher ratio of “without symptom” in runny nose, plugged nose, sneezing, sore throat, hoarseness, cough, headache, feeling tired, and fever than the placebo group, indicating that the incidence rates of common cold symptoms were lower in the LG2055 group. Additionally, changes in the salivary secretory IgA levels were significantly higher, and the serum derivatives of reactive oxygen metabolites levels were significantly lower in the LG2055 group.ConclusionOur study revealed that intake of LG2055 decreased common cold symptoms and improved immune parameters in healthy adults. This suggests that LG2055 contributes to the maintenance of physical conditions by improving the host immune system.Clinical trial registration[https://www.umin.ac.jp/ctr/index.htm], identifier [UMIN000045901].https://www.frontiersin.org/articles/10.3389/fnut.2022.1063584/fullLactobacillus paragasseri SBT2055probioticsclinical studysubjective symptomscommon coldsalivary sIgA |
| spellingShingle | Eiji Kobatake Yoshitaka Iwama Toshinobu Arai Nobuhiko Shioya Mai Kise Toshihide Kabuki Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study Frontiers in Nutrition Lactobacillus paragasseri SBT2055 probiotics clinical study subjective symptoms common cold salivary sIgA |
| title | Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study |
| title_full | Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study |
| title_fullStr | Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study |
| title_full_unstemmed | Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study |
| title_short | Intake of Lactobacillus paragasseri SBT2055 improves subjective symptoms of common cold during winter season in healthy adults: A randomized, double-blind, placebo-controlled parallel-group comparative study |
| title_sort | intake of lactobacillus paragasseri sbt2055 improves subjective symptoms of common cold during winter season in healthy adults a randomized double blind placebo controlled parallel group comparative study |
| topic | Lactobacillus paragasseri SBT2055 probiotics clinical study subjective symptoms common cold salivary sIgA |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1063584/full |
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