The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population
Zhiyuan Wu,1,* Yufeng Liang,1,* Yunlong Zuo,1,* Yufen Xu,2 Hanran Mai,2 Lei Pi,2 Di Che,2 Xiaoqiong Gu2 1Pediatric Intensive Care Unit. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Department of Clinical...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-08-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/the-lncrna-ccat2-rs6983267-g-variant-contributes-to-increased-sepsis-s-peer-reviewed-fulltext-article-IDR |
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| author | Wu Z Liang Y Zuo Y Xu Y Mai H Pi L Che D Gu X |
| author_facet | Wu Z Liang Y Zuo Y Xu Y Mai H Pi L Che D Gu X |
| author_sort | Wu Z |
| collection | DOAJ |
| description | Zhiyuan Wu,1,* Yufeng Liang,1,* Yunlong Zuo,1,* Yufen Xu,2 Hanran Mai,2 Lei Pi,2 Di Che,2 Xiaoqiong Gu2 1Pediatric Intensive Care Unit. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoqiong Gu; Di CheDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of ChinaTel/Fax +86-20-38076561; +86-20-38076562Email guxiaoqiong@gwcmc.org; chedi@gwcmc.orgPurpose: Accumulating evidence demonstrates that genetic susceptibility genes can be used as biomarkers to assess sepsis susceptibility, and genetic variation is associated with susceptibility and clinical outcomes in patients with sepsis and inflammatory disease. Although studies have shown that the lncRNA CCAT2 is involved in inflammatory diseases, it remains unclear whether CCAT2 gene polymorphisms are associated with susceptibility to inflammatory diseases, such as sepsis, in children.Methods: We genotyped the rs6983267 CCAT2 polymorphism in 474 cases (pediatric sepsis) and 678 controls using TaqMan methods, and odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of associations.Results: Our results indicate that the rs6983267 T > G polymorphism is significantly associated with an increased risk of sepsis in children (TG and TT: adjusted OR = 1.311, 95% CI = 1.016– 1.743, GG and TT: adjusted OR = 1.444, 95% CI = 1.025– 2.034 dominant model: GG/TG vs TT adjusted OR = 1.362, 95% CI = 1.055– 1.756). Furthermore, the risk effect was more pronounced in children younger than 60 months who were male and who had sepsis.Conclusion: We found that the CCAT2 gene polymorphism rs6983267 T > G may be associated with an increased risk of pediatric sepsis in southern China. A larger multicenter study should be performed to confirm these results.Keywords: lncRNA CCAT2, sepsis, susceptibility, polymorphism |
| first_indexed | 2024-12-22T09:06:36Z |
| format | Article |
| id | doaj.art-99543d98fa314daeaeb430f80fa695db |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-22T09:06:36Z |
| publishDate | 2021-08-01 |
| publisher | Dove Medical Press |
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| series | Infection and Drug Resistance |
| spelling | doaj.art-99543d98fa314daeaeb430f80fa695db2022-12-21T18:31:34ZengDove Medical PressInfection and Drug Resistance1178-69732021-08-01Volume 142969297667544The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese PopulationWu ZLiang YZuo YXu YMai HPi LChe DGu XZhiyuan Wu,1,* Yufeng Liang,1,* Yunlong Zuo,1,* Yufen Xu,2 Hanran Mai,2 Lei Pi,2 Di Che,2 Xiaoqiong Gu2 1Pediatric Intensive Care Unit. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoqiong Gu; Di CheDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of ChinaTel/Fax +86-20-38076561; +86-20-38076562Email guxiaoqiong@gwcmc.org; chedi@gwcmc.orgPurpose: Accumulating evidence demonstrates that genetic susceptibility genes can be used as biomarkers to assess sepsis susceptibility, and genetic variation is associated with susceptibility and clinical outcomes in patients with sepsis and inflammatory disease. Although studies have shown that the lncRNA CCAT2 is involved in inflammatory diseases, it remains unclear whether CCAT2 gene polymorphisms are associated with susceptibility to inflammatory diseases, such as sepsis, in children.Methods: We genotyped the rs6983267 CCAT2 polymorphism in 474 cases (pediatric sepsis) and 678 controls using TaqMan methods, and odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of associations.Results: Our results indicate that the rs6983267 T > G polymorphism is significantly associated with an increased risk of sepsis in children (TG and TT: adjusted OR = 1.311, 95% CI = 1.016– 1.743, GG and TT: adjusted OR = 1.444, 95% CI = 1.025– 2.034 dominant model: GG/TG vs TT adjusted OR = 1.362, 95% CI = 1.055– 1.756). Furthermore, the risk effect was more pronounced in children younger than 60 months who were male and who had sepsis.Conclusion: We found that the CCAT2 gene polymorphism rs6983267 T > G may be associated with an increased risk of pediatric sepsis in southern China. A larger multicenter study should be performed to confirm these results.Keywords: lncRNA CCAT2, sepsis, susceptibility, polymorphismhttps://www.dovepress.com/the-lncrna-ccat2-rs6983267-g-variant-contributes-to-increased-sepsis-s-peer-reviewed-fulltext-article-IDRlncrna ccat2sepsissusceptibilitypolymorphism |
| spellingShingle | Wu Z Liang Y Zuo Y Xu Y Mai H Pi L Che D Gu X The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population Infection and Drug Resistance lncrna ccat2 sepsis susceptibility polymorphism |
| title | The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population |
| title_full | The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population |
| title_fullStr | The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population |
| title_full_unstemmed | The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population |
| title_short | The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population |
| title_sort | lncrna ccat2 rs6983267 g variant contributes to increased sepsis susceptibility in a southern chinese population |
| topic | lncrna ccat2 sepsis susceptibility polymorphism |
| url | https://www.dovepress.com/the-lncrna-ccat2-rs6983267-g-variant-contributes-to-increased-sepsis-s-peer-reviewed-fulltext-article-IDR |
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