MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2 (Forkhead Box P2)
Glioblastoma (GBM) is the most malignant tumor in the central nervous system and the treatment is still unsatisfactory because the mechanism of the disease remains unclear. The abnormal expression of miRNAs and its target proteins play a crucial role in the development of glioblastoma. In this study...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.01176/full |
| _version_ | 1819062889782181888 |
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| author | Hongbo Zhang Hongbo Zhang Yuntao Li Yuntao Li Yinqiu Tan Qi Liu Shuting Jiang Dongyuan Liu Qianxue Chen Shizhong Zhang Shizhong Zhang |
| author_facet | Hongbo Zhang Hongbo Zhang Yuntao Li Yuntao Li Yinqiu Tan Qi Liu Shuting Jiang Dongyuan Liu Qianxue Chen Shizhong Zhang Shizhong Zhang |
| author_sort | Hongbo Zhang |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most malignant tumor in the central nervous system and the treatment is still unsatisfactory because the mechanism of the disease remains unclear. The abnormal expression of miRNAs and its target proteins play a crucial role in the development of glioblastoma. In this study, we demonstrated that high expression of miR-9-5p and low expression of forkhead box P2 (FOXP2) were related with better outcome in patients with GBM, and down regulated FOXP2 expression was able to inhibit glioma cells proliferation by cell cycle arrest. Furthermore, we found that FOXP2 was the target protein of miR-9-5p in luciferase assay. The results of this study suggest a novel regulatory mechanism that miR-9-5p can inhibit glioma cells proliferation by downregulating FOXP2. |
| first_indexed | 2024-12-21T15:05:57Z |
| format | Article |
| id | doaj.art-99561c85e7794f2aa695721f7fcbf989 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T15:05:57Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-99561c85e7794f2aa695721f7fcbf9892022-12-21T18:59:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-11-01910.3389/fonc.2019.01176470675MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2 (Forkhead Box P2)Hongbo Zhang0Hongbo Zhang1Yuntao Li2Yuntao Li3Yinqiu Tan4Qi Liu5Shuting Jiang6Dongyuan Liu7Qianxue Chen8Shizhong Zhang9Shizhong Zhang10Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The National Key Clinic Specialty, The Engineering Technology Research Center of Education Ministry of China, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, ChinaDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurosurgery, Huzhou Central Hospital, Zhejiang University School of Medicine, Huzhou, ChinaDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The National Key Clinic Specialty, The Engineering Technology Research Center of Education Ministry of China, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, ChinaGlioblastoma (GBM) is the most malignant tumor in the central nervous system and the treatment is still unsatisfactory because the mechanism of the disease remains unclear. The abnormal expression of miRNAs and its target proteins play a crucial role in the development of glioblastoma. In this study, we demonstrated that high expression of miR-9-5p and low expression of forkhead box P2 (FOXP2) were related with better outcome in patients with GBM, and down regulated FOXP2 expression was able to inhibit glioma cells proliferation by cell cycle arrest. Furthermore, we found that FOXP2 was the target protein of miR-9-5p in luciferase assay. The results of this study suggest a novel regulatory mechanism that miR-9-5p can inhibit glioma cells proliferation by downregulating FOXP2.https://www.frontiersin.org/article/10.3389/fonc.2019.01176/fullmiR-9-5pFOXP2glioblastomaproliferationglioma |
| spellingShingle | Hongbo Zhang Hongbo Zhang Yuntao Li Yuntao Li Yinqiu Tan Qi Liu Shuting Jiang Dongyuan Liu Qianxue Chen Shizhong Zhang Shizhong Zhang MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2 (Forkhead Box P2) Frontiers in Oncology miR-9-5p FOXP2 glioblastoma proliferation glioma |
| title | MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2 (Forkhead Box P2) |
| title_full | MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2 (Forkhead Box P2) |
| title_fullStr | MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2 (Forkhead Box P2) |
| title_full_unstemmed | MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2 (Forkhead Box P2) |
| title_short | MiR-9-5p Inhibits Glioblastoma Cells Proliferation Through Directly Targeting FOXP2 (Forkhead Box P2) |
| title_sort | mir 9 5p inhibits glioblastoma cells proliferation through directly targeting foxp2 forkhead box p2 |
| topic | miR-9-5p FOXP2 glioblastoma proliferation glioma |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.01176/full |
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