Preliminary outcomes of DEB-TACE loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinoma
Abstract Purpose Raltitrexed shows therapeutic effects and safety in many types of malignant tumors. However, reports of the clinical outcomes of raltitrexed-based transarterial chemoembolization (TACE) or drug-eluting beads TACE (DEB-TACE) in the treatment of hepatocellular carcinoma (HCC) are rare...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Cancer Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40644-023-00534-1 |
| _version_ | 1797863686876954624 |
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| author | Yonghua Bi Yang Wang Wenguang Zhang Huibin Lu Jianzhuang Ren Xinwei Han |
| author_facet | Yonghua Bi Yang Wang Wenguang Zhang Huibin Lu Jianzhuang Ren Xinwei Han |
| author_sort | Yonghua Bi |
| collection | DOAJ |
| description | Abstract Purpose Raltitrexed shows therapeutic effects and safety in many types of malignant tumors. However, reports of the clinical outcomes of raltitrexed-based transarterial chemoembolization (TACE) or drug-eluting beads TACE (DEB-TACE) in the treatment of hepatocellular carcinoma (HCC) are rare. We aim to report the preliminary outcomes of DEB-TACE loaded with raltitrexed in patients with unresectable or recurrent HCC. Methods From June 2018 to March 2020, 29 patients with unresectable or recurrent HCC were recruited from our department and treated by DEB-TACE loaded with raltitrexed. Overall survival and progression-free survival were the primary end points. Tumor response was investigated by using the modified response evaluation criteria in solid tumors (mRECIST) criteria. Results A total of 49 sessions of DEB-TACE were performed, with a technique success rate of 100%. The overall response rate and disease control rate at 1, 3, and 6 months after DEB-TACE were 72.0% and 96.0%, 57.1% and 85.7%, 47.6% and 66.7% respectively. The median progression-free survival and overall survival was 25.7 and 33.9 months, respectively. The 6-, 24- and 36-month overall survival rates were 88.4%, 66.3% and 46.3%, respectively. Minor complications were observed in 17 patients (58.6%), with no treatment-related mortality or severe adverse events. The most common treatment-related complications were abdominal pain (41.4%) and elevated ALT/AST (27.6%). Conclusion DEB-TACE loaded with raltitrexed is suggested as a safe, feasible, efficacious palliative regimen in unresectable or recurrent HCC patients. |
| first_indexed | 2024-04-09T22:39:32Z |
| format | Article |
| id | doaj.art-995aa6760f674bf7b06553f39d912390 |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-04-09T22:39:32Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-995aa6760f674bf7b06553f39d9123902023-03-22T12:15:21ZengBMCCancer Imaging1470-73302023-02-012311910.1186/s40644-023-00534-1Preliminary outcomes of DEB-TACE loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinomaYonghua Bi0Yang Wang1Wenguang Zhang2Huibin Lu3Jianzhuang Ren4Xinwei Han5Department of Interventional Radiology, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Interventional Radiology, the First Affiliated Hospital of Zhengzhou UniversityAbstract Purpose Raltitrexed shows therapeutic effects and safety in many types of malignant tumors. However, reports of the clinical outcomes of raltitrexed-based transarterial chemoembolization (TACE) or drug-eluting beads TACE (DEB-TACE) in the treatment of hepatocellular carcinoma (HCC) are rare. We aim to report the preliminary outcomes of DEB-TACE loaded with raltitrexed in patients with unresectable or recurrent HCC. Methods From June 2018 to March 2020, 29 patients with unresectable or recurrent HCC were recruited from our department and treated by DEB-TACE loaded with raltitrexed. Overall survival and progression-free survival were the primary end points. Tumor response was investigated by using the modified response evaluation criteria in solid tumors (mRECIST) criteria. Results A total of 49 sessions of DEB-TACE were performed, with a technique success rate of 100%. The overall response rate and disease control rate at 1, 3, and 6 months after DEB-TACE were 72.0% and 96.0%, 57.1% and 85.7%, 47.6% and 66.7% respectively. The median progression-free survival and overall survival was 25.7 and 33.9 months, respectively. The 6-, 24- and 36-month overall survival rates were 88.4%, 66.3% and 46.3%, respectively. Minor complications were observed in 17 patients (58.6%), with no treatment-related mortality or severe adverse events. The most common treatment-related complications were abdominal pain (41.4%) and elevated ALT/AST (27.6%). Conclusion DEB-TACE loaded with raltitrexed is suggested as a safe, feasible, efficacious palliative regimen in unresectable or recurrent HCC patients.https://doi.org/10.1186/s40644-023-00534-1CarcinomaHepatocellularChemoembolizationTherapeuticMicrospheresRaltitrexed |
| spellingShingle | Yonghua Bi Yang Wang Wenguang Zhang Huibin Lu Jianzhuang Ren Xinwei Han Preliminary outcomes of DEB-TACE loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinoma Cancer Imaging Carcinoma Hepatocellular Chemoembolization Therapeutic Microspheres Raltitrexed |
| title | Preliminary outcomes of DEB-TACE loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinoma |
| title_full | Preliminary outcomes of DEB-TACE loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinoma |
| title_fullStr | Preliminary outcomes of DEB-TACE loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinoma |
| title_full_unstemmed | Preliminary outcomes of DEB-TACE loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinoma |
| title_short | Preliminary outcomes of DEB-TACE loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinoma |
| title_sort | preliminary outcomes of deb tace loaded with raltitrexed in the treatment of unresectable or recurrent hepatocellular carcinoma |
| topic | Carcinoma Hepatocellular Chemoembolization Therapeutic Microspheres Raltitrexed |
| url | https://doi.org/10.1186/s40644-023-00534-1 |
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