Third‐Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort Study
Background Limited data are available for postpartum hypertension prediction after preeclampsia. Methods and Results We examined the association between maternal serum chemerin levels in patients with preeclampsia and blood pressure (BP) levels after delivery in a prospective birth cohort of 15 041...
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.027930 |
| _version_ | 1827572757563441152 |
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| author | Yixuan Chen Linlin Wu Hangkuan Liu Ziping Li Linjie Li Xiaoxia Wu Qiong Lei Aiqi Yin Jianing Tong Kan Liu Xiaonian Guan Cuiping Zeng Huafan Zhang Yanmei Wan Xuna Huang Pingping Huang Qing Yang Xin Zhou Jianmin Niu |
| author_facet | Yixuan Chen Linlin Wu Hangkuan Liu Ziping Li Linjie Li Xiaoxia Wu Qiong Lei Aiqi Yin Jianing Tong Kan Liu Xiaonian Guan Cuiping Zeng Huafan Zhang Yanmei Wan Xuna Huang Pingping Huang Qing Yang Xin Zhou Jianmin Niu |
| author_sort | Yixuan Chen |
| collection | DOAJ |
| description | Background Limited data are available for postpartum hypertension prediction after preeclampsia. Methods and Results We examined the association between maternal serum chemerin levels in patients with preeclampsia and blood pressure (BP) levels after delivery in a prospective birth cohort of 15 041 singleton pregnant women. A total of 310 cases among 322 patients with preeclampsia (follow‐up rate, 96.3%) were followed up during a mean 2.8 years after delivery. Compared with matched uncomplicated controls (n=310), serum chemerin measured at ≈35 gestational weeks was significantly increased in preeclampsia (171.8±49.2 versus 140.2±53.5 ng/mL; P<0.01) and positively correlated with the occurrence of postpartum hypertension, defined as either BP ≥130/80 mm Hg (per 1‐SD increase: odds ratio [OR], 4.01 [95% CI, 2.77–5.81]) or as BP ≥140/90 mm Hg (per 1‐SD increase: OR, 1.70 [95% CI, 1.28–2.25]) in patients with preeclampsia. The addition of chemerin levels improved the predictive performance of the clinical variable‐derived prediction models for postpartum hypertension (for BP ≥130/80 mm Hg: area under the curve, 0.903 [95% CI, 0.869–0.937], Δ area under the curve, 0.070, P<0.001; for BP ≥140/90 mm Hg: area under the curve, 0.852 [95% CI, 0.803–0.902], Δ area under the curve, 0.030, P=0.002). The decision curve analysis revealed a net benefit of the chemerin‐based prediction model for postpartum BP ≥130/80 mm Hg. Conclusions This study provides the first evidence supporting the independent predictive role of third‐trimester maternal chemerin levels for postpartum hypertension after preeclampsia. Future study is warranted for external validation of this finding. |
| first_indexed | 2024-03-07T19:22:05Z |
| format | Article |
| id | doaj.art-995cab6450eb41b9921d984fc6df6949 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-07T19:22:05Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-995cab6450eb41b9921d984fc6df69492024-02-29T10:25:12ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-03-0112510.1161/JAHA.122.027930Third‐Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort StudyYixuan Chen0Linlin Wu1Hangkuan Liu2Ziping Li3Linjie Li4Xiaoxia Wu5Qiong Lei6Aiqi Yin7Jianing Tong8Kan Liu9Xiaonian Guan10Cuiping Zeng11Huafan Zhang12Yanmei Wan13Xuna Huang14Pingping Huang15Qing Yang16Xin Zhou17Jianmin Niu18Department of Obstetrics Shenzhen Maternity and Child Healthcare Hospital Shenzhen Guangdong ChinaDepartment of Obstetrics and Gynecology, the Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen Guangdong ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Obstetrics Shenzhen Maternity and Child Healthcare Hospital Shenzhen Guangdong ChinaDepartment of Obstetrics and Gynecology, the Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen Guangdong ChinaDepartment of Obstetrics Shenzhen Maternity and Child Healthcare Hospital Shenzhen Guangdong ChinaDepartment of Obstetrics and Gynecology, the Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen Guangdong ChinaDepartment of Obstetrics Shenzhen Maternity and Child Healthcare Hospital Shenzhen Guangdong ChinaDepartment of Obstetrics Shenzhen Maternity and Child Healthcare Hospital Shenzhen Guangdong ChinaDepartment of Obstetrics and Gynecology, the Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen Guangdong ChinaDepartment of Obstetrics Shenzhen Maternity and Child Healthcare Hospital Shenzhen Guangdong ChinaDepartment of Obstetrics Shenzhen Maternity and Child Healthcare Hospital Shenzhen Guangdong ChinaDepartment of Obstetrics Shenzhen Maternity and Child Healthcare Hospital Shenzhen Guangdong ChinaDepartment of Obstetrics and Gynecology, the Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen Guangdong ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Cardiology Tianjin Medical University General Hospital Tianjin ChinaDepartment of Obstetrics Shenzhen Maternity and Child Healthcare Hospital Shenzhen Guangdong ChinaBackground Limited data are available for postpartum hypertension prediction after preeclampsia. Methods and Results We examined the association between maternal serum chemerin levels in patients with preeclampsia and blood pressure (BP) levels after delivery in a prospective birth cohort of 15 041 singleton pregnant women. A total of 310 cases among 322 patients with preeclampsia (follow‐up rate, 96.3%) were followed up during a mean 2.8 years after delivery. Compared with matched uncomplicated controls (n=310), serum chemerin measured at ≈35 gestational weeks was significantly increased in preeclampsia (171.8±49.2 versus 140.2±53.5 ng/mL; P<0.01) and positively correlated with the occurrence of postpartum hypertension, defined as either BP ≥130/80 mm Hg (per 1‐SD increase: odds ratio [OR], 4.01 [95% CI, 2.77–5.81]) or as BP ≥140/90 mm Hg (per 1‐SD increase: OR, 1.70 [95% CI, 1.28–2.25]) in patients with preeclampsia. The addition of chemerin levels improved the predictive performance of the clinical variable‐derived prediction models for postpartum hypertension (for BP ≥130/80 mm Hg: area under the curve, 0.903 [95% CI, 0.869–0.937], Δ area under the curve, 0.070, P<0.001; for BP ≥140/90 mm Hg: area under the curve, 0.852 [95% CI, 0.803–0.902], Δ area under the curve, 0.030, P=0.002). The decision curve analysis revealed a net benefit of the chemerin‐based prediction model for postpartum BP ≥130/80 mm Hg. Conclusions This study provides the first evidence supporting the independent predictive role of third‐trimester maternal chemerin levels for postpartum hypertension after preeclampsia. Future study is warranted for external validation of this finding.https://www.ahajournals.org/doi/10.1161/JAHA.122.027930biomarkerchemerinhypertensionprediction modelpreeclampsia |
| spellingShingle | Yixuan Chen Linlin Wu Hangkuan Liu Ziping Li Linjie Li Xiaoxia Wu Qiong Lei Aiqi Yin Jianing Tong Kan Liu Xiaonian Guan Cuiping Zeng Huafan Zhang Yanmei Wan Xuna Huang Pingping Huang Qing Yang Xin Zhou Jianmin Niu Third‐Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease biomarker chemerin hypertension prediction model preeclampsia |
| title | Third‐Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort Study |
| title_full | Third‐Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort Study |
| title_fullStr | Third‐Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort Study |
| title_full_unstemmed | Third‐Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort Study |
| title_short | Third‐Trimester Maternal Serum Chemerin and Hypertension After Preeclampsia: A Prospective Cohort Study |
| title_sort | third trimester maternal serum chemerin and hypertension after preeclampsia a prospective cohort study |
| topic | biomarker chemerin hypertension prediction model preeclampsia |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.027930 |
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