Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer

Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer

Objective The objective of this study was to investigate the inhibitory effect of sophocarpine on the progression of castration-resistant prostate cancer (CRPC) and the underlying molecular mechanism. Methods DU145 and PC3 cells (two CRPC cell lines), incubated with different concentrations of sopho...

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Bibliographic Details
Main Authors: Min Weng, Chenghao Shi, Hui Han, Hengyue Zhu, Yanyi Xiao, Hangcheng Guo, Zhixian Yu, Cunzao Wu
Format: Article
Language:English
Published: PeerJ Inc. 2022-09-01
Series:PeerJ
Subjects:
Castration-resistant prostate cancer
Sophocarpine
mTOR
Proliferation
Epithelial-mesenchymal transition
Online Access:https://peerj.com/articles/14042.pdf

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