Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy
Background: Maternal vaccination is safe and provides protection against COVID-19 in mothers and neonates, and it is necessary to evaluate its effect on the induction of immune responses through the levels of neutralizing antibodies present in maternal and neonatal blood. Methods: An observational s...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/3/620 |
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| author | Antônio Oliveira da Silva Filho Daniel Nazário Gonçalves Letícia Karina Ramos de Lima Dâmocles Aurélio Nascimento da Silva Alves Felipe José de Andrade Falcão Rosângela Estevão Alves Falcão |
| author_facet | Antônio Oliveira da Silva Filho Daniel Nazário Gonçalves Letícia Karina Ramos de Lima Dâmocles Aurélio Nascimento da Silva Alves Felipe José de Andrade Falcão Rosângela Estevão Alves Falcão |
| author_sort | Antônio Oliveira da Silva Filho |
| collection | DOAJ |
| description | Background: Maternal vaccination is safe and provides protection against COVID-19 in mothers and neonates, and it is necessary to evaluate its effect on the induction of immune responses through the levels of neutralizing antibodies present in maternal and neonatal blood. Methods: An observational study with transversal analysis was carried out. Included in the research were neonates (<1 month) whose mothers had been immunized whilst pregnant with at least one dose of the vaccine BNT16b and had not shown any symptoms of COVID-19. The blood of the mothers and newborns was collected during the Guthrie test and sent to the laboratory for the detection of neutralizing antibodies against SARS-CoV-2. Results: A total of 162 pairs of mothers and neonates were analyzed with an average age of 26.3 ± 5.97 years and 13.4 ± 6.90 days, respectively. All samples collected present neutralizing antibodies with an average percentage of 91% in the mothers and 92% in the neonates. The most satisfactory immune response was observed in neonates and mothers vaccinated during the second trimester of gestation. Conclusions: The vaccination of expectant mothers with the immunizer BNT162b2 has promoted a robust immunological response in both the mothers and the neonates. |
| first_indexed | 2024-03-11T05:48:21Z |
| format | Article |
| id | doaj.art-995f9fcf43f54eaa99c00f452b508519 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T05:48:21Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-995f9fcf43f54eaa99c00f452b5085192023-11-17T14:18:37ZengMDPI AGVaccines2076-393X2023-03-0111362010.3390/vaccines11030620Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during PregnancyAntônio Oliveira da Silva Filho0Daniel Nazário Gonçalves1Letícia Karina Ramos de Lima2Dâmocles Aurélio Nascimento da Silva Alves3Felipe José de Andrade Falcão4Rosângela Estevão Alves Falcão5Post-Graduate Program in Health and Socio-Environmental Development Multicampi Garanhuns, University of Pernambuco, Garanhuns 55294-310, BrazilDepartment of Health Sciences, Multicampi Garanhuns, University of Pernambuco, Garanhuns 55294-310, BrazilDepartment of Exact Sciences, Multicampi Garanhuns, University of Pernambuco, Garanhuns 55294-310, BrazilDepartment of Exact Sciences, Multicampi Garanhuns, University of Pernambuco, Garanhuns 55294-310, BrazilDepartment of Health Sciences, Multicampi Garanhuns, University of Pernambuco, Garanhuns 55294-310, BrazilPost-Graduate Program in Health and Socio-Environmental Development Multicampi Garanhuns, University of Pernambuco, Garanhuns 55294-310, BrazilBackground: Maternal vaccination is safe and provides protection against COVID-19 in mothers and neonates, and it is necessary to evaluate its effect on the induction of immune responses through the levels of neutralizing antibodies present in maternal and neonatal blood. Methods: An observational study with transversal analysis was carried out. Included in the research were neonates (<1 month) whose mothers had been immunized whilst pregnant with at least one dose of the vaccine BNT16b and had not shown any symptoms of COVID-19. The blood of the mothers and newborns was collected during the Guthrie test and sent to the laboratory for the detection of neutralizing antibodies against SARS-CoV-2. Results: A total of 162 pairs of mothers and neonates were analyzed with an average age of 26.3 ± 5.97 years and 13.4 ± 6.90 days, respectively. All samples collected present neutralizing antibodies with an average percentage of 91% in the mothers and 92% in the neonates. The most satisfactory immune response was observed in neonates and mothers vaccinated during the second trimester of gestation. Conclusions: The vaccination of expectant mothers with the immunizer BNT162b2 has promoted a robust immunological response in both the mothers and the neonates.https://www.mdpi.com/2076-393X/11/3/620COVID-19maternal immunizationneutralizing antibodiesSARS-CoV-2BNT162b2 |
| spellingShingle | Antônio Oliveira da Silva Filho Daniel Nazário Gonçalves Letícia Karina Ramos de Lima Dâmocles Aurélio Nascimento da Silva Alves Felipe José de Andrade Falcão Rosângela Estevão Alves Falcão Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy Vaccines COVID-19 maternal immunization neutralizing antibodies SARS-CoV-2 BNT162b2 |
| title | Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy |
| title_full | Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy |
| title_fullStr | Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy |
| title_full_unstemmed | Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy |
| title_short | Levels of Neutralizing Antibodies against SARS-CoV-2 in Mothers and Neonates after Vaccination during Pregnancy |
| title_sort | levels of neutralizing antibodies against sars cov 2 in mothers and neonates after vaccination during pregnancy |
| topic | COVID-19 maternal immunization neutralizing antibodies SARS-CoV-2 BNT162b2 |
| url | https://www.mdpi.com/2076-393X/11/3/620 |
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