Cannabinoids and Cannabinoid Receptors: The Story so Far
Like most modern molecular biology and natural product chemistry, understanding cannabinoid pharmacology centers around molecular interactions, in this case, between the cannabinoids and their putative targets, the G-protein coupled receptors (GPCRs) cannabinoid receptor 1 (CB1) and cannabinoid rece...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220304880 |
| _version_ | 1818118191249883136 |
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| author | Fred Shahbazi Victoria Grandi Abhinandan Banerjee John F. Trant |
| author_facet | Fred Shahbazi Victoria Grandi Abhinandan Banerjee John F. Trant |
| author_sort | Fred Shahbazi |
| collection | DOAJ |
| description | Like most modern molecular biology and natural product chemistry, understanding cannabinoid pharmacology centers around molecular interactions, in this case, between the cannabinoids and their putative targets, the G-protein coupled receptors (GPCRs) cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). Understanding the complex structure and interplay between the partners in this molecular dance is required to understand the mechanism of action of synthetic, endogenous, and phytochemical cannabinoids. This review, with 91 references, surveys our understanding of the structural biology of the cannabinoids and their target receptors including both a critical comparison of the extant crystal structures and the computationally derived homology models, as well as an in-depth discussion about the binding modes of the major cannabinoids. The aim is to assist in situating structural biochemists, synthetic chemists, and molecular biologists who are new to the field of cannabis research. |
| first_indexed | 2024-12-11T04:50:23Z |
| format | Article |
| id | doaj.art-995fbcf8d2594cadae1efe414571296a |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-11T04:50:23Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-995fbcf8d2594cadae1efe414571296a2022-12-22T01:20:24ZengElsevieriScience2589-00422020-07-01237101301Cannabinoids and Cannabinoid Receptors: The Story so FarFred Shahbazi0Victoria Grandi1Abhinandan Banerjee2John F. Trant3Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, CanadaDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON N9B 3P4, Canada; Corresponding authorLike most modern molecular biology and natural product chemistry, understanding cannabinoid pharmacology centers around molecular interactions, in this case, between the cannabinoids and their putative targets, the G-protein coupled receptors (GPCRs) cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). Understanding the complex structure and interplay between the partners in this molecular dance is required to understand the mechanism of action of synthetic, endogenous, and phytochemical cannabinoids. This review, with 91 references, surveys our understanding of the structural biology of the cannabinoids and their target receptors including both a critical comparison of the extant crystal structures and the computationally derived homology models, as well as an in-depth discussion about the binding modes of the major cannabinoids. The aim is to assist in situating structural biochemists, synthetic chemists, and molecular biologists who are new to the field of cannabis research.http://www.sciencedirect.com/science/article/pii/S2589004220304880Medical SubstanceSupramolecular ChemistryMolecular BiologyStructural Biology |
| spellingShingle | Fred Shahbazi Victoria Grandi Abhinandan Banerjee John F. Trant Cannabinoids and Cannabinoid Receptors: The Story so Far iScience Medical Substance Supramolecular Chemistry Molecular Biology Structural Biology |
| title | Cannabinoids and Cannabinoid Receptors: The Story so Far |
| title_full | Cannabinoids and Cannabinoid Receptors: The Story so Far |
| title_fullStr | Cannabinoids and Cannabinoid Receptors: The Story so Far |
| title_full_unstemmed | Cannabinoids and Cannabinoid Receptors: The Story so Far |
| title_short | Cannabinoids and Cannabinoid Receptors: The Story so Far |
| title_sort | cannabinoids and cannabinoid receptors the story so far |
| topic | Medical Substance Supramolecular Chemistry Molecular Biology Structural Biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220304880 |
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