Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging
Estrogen (E2) plays important role in regulating hippocampal learning and memory. The decline of E2 after menopause affects learning and memory and increases the risk of neurodegenerative diseases like Alzheimer's disease (AD). Additionally, from the estrogen receptor (ER) mediated gene regulat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.945076/full |
| _version_ | 1818507458080931840 |
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| author | Padmanabh Singh Vijay Paramanik |
| author_facet | Padmanabh Singh Vijay Paramanik |
| author_sort | Padmanabh Singh |
| collection | DOAJ |
| description | Estrogen (E2) plays important role in regulating hippocampal learning and memory. The decline of E2 after menopause affects learning and memory and increases the risk of neurodegenerative diseases like Alzheimer's disease (AD). Additionally, from the estrogen receptor (ER) mediated gene regulation; E2 also regulates gene expression at the transcriptional and posttranscriptional levels through epigenetic modifications. E2 recruits a number of proteins called co-regulators at the promoter region of genes. These co-regulators act as chromatin modifiers, alter DNA and histone modifications and regulate gene expression. Several studies show that E2 regulates learning and memory by altering chromatin at the promoters of memory-linked genes. Due to structural similarities with E2 and low side effects, phytoestrogens are now used as neuroprotective agents to recover learning and memory in animal models as well as human subjects during aging and different neurological disorders. Growing evidence suggests that apart from anti-oxidative and anti-inflammatory properties, phytoestrogens also act as epigenetic modifiers and regulate gene expression through epigenetic modifications. The epigenetic modifying properties of phytoestrogens are mostly studied in cancer cells but very little is known regarding the regulation of synaptic plasticity genes, learning and memory, and neurological disorders. In this article, we discuss the epigenetic modifying properties of E2 and the roles of phytoestrogens as epigenetic modifiers in the brain to recover and maintain cognitive functions. |
| first_indexed | 2024-12-10T22:18:39Z |
| format | Article |
| id | doaj.art-9962731d8a06480abfb1dbddac015673 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-10T22:18:39Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-9962731d8a06480abfb1dbddac0156732022-12-22T01:31:23ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.945076945076Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during agingPadmanabh SinghVijay ParamanikEstrogen (E2) plays important role in regulating hippocampal learning and memory. The decline of E2 after menopause affects learning and memory and increases the risk of neurodegenerative diseases like Alzheimer's disease (AD). Additionally, from the estrogen receptor (ER) mediated gene regulation; E2 also regulates gene expression at the transcriptional and posttranscriptional levels through epigenetic modifications. E2 recruits a number of proteins called co-regulators at the promoter region of genes. These co-regulators act as chromatin modifiers, alter DNA and histone modifications and regulate gene expression. Several studies show that E2 regulates learning and memory by altering chromatin at the promoters of memory-linked genes. Due to structural similarities with E2 and low side effects, phytoestrogens are now used as neuroprotective agents to recover learning and memory in animal models as well as human subjects during aging and different neurological disorders. Growing evidence suggests that apart from anti-oxidative and anti-inflammatory properties, phytoestrogens also act as epigenetic modifiers and regulate gene expression through epigenetic modifications. The epigenetic modifying properties of phytoestrogens are mostly studied in cancer cells but very little is known regarding the regulation of synaptic plasticity genes, learning and memory, and neurological disorders. In this article, we discuss the epigenetic modifying properties of E2 and the roles of phytoestrogens as epigenetic modifiers in the brain to recover and maintain cognitive functions.https://www.frontiersin.org/articles/10.3389/fnagi.2022.945076/fullestrogensphytoestrogensepigenetic modificationscognitive functionsbrain |
| spellingShingle | Padmanabh Singh Vijay Paramanik Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging Frontiers in Aging Neuroscience estrogens phytoestrogens epigenetic modifications cognitive functions brain |
| title | Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging |
| title_full | Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging |
| title_fullStr | Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging |
| title_full_unstemmed | Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging |
| title_short | Neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging |
| title_sort | neuromodulating roles of estrogen and phytoestrogens in cognitive therapeutics through epigenetic modifications during aging |
| topic | estrogens phytoestrogens epigenetic modifications cognitive functions brain |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.945076/full |
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