Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms
Nature’s library of venoms is a vast and untapped resource that has the potential of becoming the source of a wide variety of new drugs and therapeutics. The discovery of these valuable molecules, hidden in diverse collections of different venoms, requires highly specific genetic and proteomic seque...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/13/2/154 |
| _version_ | 1797396335978086400 |
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| author | Stephanie Mouchbahani-Constance Reza Sharif-Naeini |
| author_facet | Stephanie Mouchbahani-Constance Reza Sharif-Naeini |
| author_sort | Stephanie Mouchbahani-Constance |
| collection | DOAJ |
| description | Nature’s library of venoms is a vast and untapped resource that has the potential of becoming the source of a wide variety of new drugs and therapeutics. The discovery of these valuable molecules, hidden in diverse collections of different venoms, requires highly specific genetic and proteomic sequencing techniques. These have been used to sequence a variety of venom glands from species ranging from snakes to scorpions, and some marine species. In addition to identifying toxin sequences, these techniques have paved the way for identifying various novel evolutionary links between species that were previously thought to be unrelated. Furthermore, proteomics-based techniques have allowed researchers to discover how specific toxins have evolved within related species, and in the context of environmental pressures. These techniques allow groups to discover novel proteins, identify mutations of interest, and discover new ways to modify toxins for biomimetic purposes and for the development of new therapeutics. |
| first_indexed | 2024-03-09T00:49:45Z |
| format | Article |
| id | doaj.art-996321afb5b64b2abb3a00fbe4ea0ba0 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T00:49:45Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-996321afb5b64b2abb3a00fbe4ea0ba02023-12-11T17:17:53ZengMDPI AGToxins2072-66512021-02-0113215410.3390/toxins13020154Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of VenomsStephanie Mouchbahani-Constance0Reza Sharif-Naeini1Department of Physiology and Cell Information Systems Group, Alan Edwards Center for Research on Pain, McGill University, Montreal, QC H3A 0G4, CanadaDepartment of Physiology and Cell Information Systems Group, Alan Edwards Center for Research on Pain, McGill University, Montreal, QC H3A 0G4, CanadaNature’s library of venoms is a vast and untapped resource that has the potential of becoming the source of a wide variety of new drugs and therapeutics. The discovery of these valuable molecules, hidden in diverse collections of different venoms, requires highly specific genetic and proteomic sequencing techniques. These have been used to sequence a variety of venom glands from species ranging from snakes to scorpions, and some marine species. In addition to identifying toxin sequences, these techniques have paved the way for identifying various novel evolutionary links between species that were previously thought to be unrelated. Furthermore, proteomics-based techniques have allowed researchers to discover how specific toxins have evolved within related species, and in the context of environmental pressures. These techniques allow groups to discover novel proteins, identify mutations of interest, and discover new ways to modify toxins for biomimetic purposes and for the development of new therapeutics.https://www.mdpi.com/2072-6651/13/2/154venomtoxinpredatorpreyhigh-performance liquid chromatographymass spectrometry |
| spellingShingle | Stephanie Mouchbahani-Constance Reza Sharif-Naeini Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms Toxins venom toxin predator prey high-performance liquid chromatography mass spectrometry |
| title | Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms |
| title_full | Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms |
| title_fullStr | Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms |
| title_full_unstemmed | Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms |
| title_short | Proteomic and Transcriptomic Techniques to Decipher the Molecular Evolution of Venoms |
| title_sort | proteomic and transcriptomic techniques to decipher the molecular evolution of venoms |
| topic | venom toxin predator prey high-performance liquid chromatography mass spectrometry |
| url | https://www.mdpi.com/2072-6651/13/2/154 |
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