Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity
Microfold cells (M cells) sit at the gut epithelial surface to sample antigens and maintain local immune homeostasis. Here the authors show that M cells are feedback-regulated by M cell-originated osteoprotegerin (OPG) to suppress RNAKL-induced M cell differentiation, and that OPG deficiency alters...
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Bibliographic Details
| Main Authors: |
Shunsuke Kimura,
Yutaka Nakamura,
Nobuhide Kobayashi,
Katsuyuki Shiroguchi,
Eiryo Kawakami,
Mami Mutoh,
Hiromi Takahashi-Iwanaga,
Takahiro Yamada,
Meri Hisamoto,
Midori Nakamura,
Nobuyuki Udagawa,
Shintaro Sato,
Tsuneyasu Kaisho,
Toshihiko Iwanaga,
Koji Hase |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-13883-y
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