Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity
Microfold cells (M cells) sit at the gut epithelial surface to sample antigens and maintain local immune homeostasis. Here the authors show that M cells are feedback-regulated by M cell-originated osteoprotegerin (OPG) to suppress RNAKL-induced M cell differentiation, and that OPG deficiency alters...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13883-y |
| _version_ | 1818427259670757376 |
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| author | Shunsuke Kimura Yutaka Nakamura Nobuhide Kobayashi Katsuyuki Shiroguchi Eiryo Kawakami Mami Mutoh Hiromi Takahashi-Iwanaga Takahiro Yamada Meri Hisamoto Midori Nakamura Nobuyuki Udagawa Shintaro Sato Tsuneyasu Kaisho Toshihiko Iwanaga Koji Hase |
| author_facet | Shunsuke Kimura Yutaka Nakamura Nobuhide Kobayashi Katsuyuki Shiroguchi Eiryo Kawakami Mami Mutoh Hiromi Takahashi-Iwanaga Takahiro Yamada Meri Hisamoto Midori Nakamura Nobuyuki Udagawa Shintaro Sato Tsuneyasu Kaisho Toshihiko Iwanaga Koji Hase |
| author_sort | Shunsuke Kimura |
| collection | DOAJ |
| description | Microfold cells (M cells) sit at the gut epithelial surface to sample antigens and maintain local immune homeostasis. Here the authors show that M cells are feedback-regulated by M cell-originated osteoprotegerin (OPG) to suppress RNAKL-induced M cell differentiation, and that OPG deficiency alters both gut colitis and infection phenotypes. |
| first_indexed | 2024-12-14T14:42:53Z |
| format | Article |
| id | doaj.art-99645e0b7f85428f9c603bf38fe18aa1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:42:53Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-99645e0b7f85428f9c603bf38fe18aa12022-12-21T22:57:22ZengNature PortfolioNature Communications2041-17232020-01-0111111610.1038/s41467-019-13883-yOsteoprotegerin-dependent M cell self-regulation balances gut infection and immunityShunsuke Kimura0Yutaka Nakamura1Nobuhide Kobayashi2Katsuyuki Shiroguchi3Eiryo Kawakami4Mami Mutoh5Hiromi Takahashi-Iwanaga6Takahiro Yamada7Meri Hisamoto8Midori Nakamura9Nobuyuki Udagawa10Shintaro Sato11Tsuneyasu Kaisho12Toshihiko Iwanaga13Koji Hase14Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio UniversityDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio UniversityDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio UniversityPRESTO, Japan Science and Technology AgencyRIKEN Medical Sciences Innovation Hub Program (MIH)Department of Orthodontics, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido UniversityLaboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido UniversityDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio UniversityDepartment of Oral Functional Prosthodontics, Division of Oral Functional Science, Graduate School of Dental Medicine, Hokkaido UniversityDepartment of Biochemistry, Matsumoto Dental UniversityDepartment of Biochemistry, Matsumoto Dental UniversityMucosal Vaccine Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Immunology, Institute of Advanced Medicine, Wakayama Medical UniversityLaboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido UniversityDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio UniversityMicrofold cells (M cells) sit at the gut epithelial surface to sample antigens and maintain local immune homeostasis. Here the authors show that M cells are feedback-regulated by M cell-originated osteoprotegerin (OPG) to suppress RNAKL-induced M cell differentiation, and that OPG deficiency alters both gut colitis and infection phenotypes.https://doi.org/10.1038/s41467-019-13883-y |
| spellingShingle | Shunsuke Kimura Yutaka Nakamura Nobuhide Kobayashi Katsuyuki Shiroguchi Eiryo Kawakami Mami Mutoh Hiromi Takahashi-Iwanaga Takahiro Yamada Meri Hisamoto Midori Nakamura Nobuyuki Udagawa Shintaro Sato Tsuneyasu Kaisho Toshihiko Iwanaga Koji Hase Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity Nature Communications |
| title | Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity |
| title_full | Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity |
| title_fullStr | Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity |
| title_full_unstemmed | Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity |
| title_short | Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity |
| title_sort | osteoprotegerin dependent m cell self regulation balances gut infection and immunity |
| url | https://doi.org/10.1038/s41467-019-13883-y |
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