Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology
Coronary artery disease (CAD) patients are at high ischemic risk, and new biomarkers reflecting atherosclerotic disease severity and coronary plaque vulnerability are required. The Brain-Derived Neurotrophic Factor (BDNF) affects endothelial and macrophage activation suggesting its involvement in at...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/11/6/1010 |
| _version_ | 1797531806481776640 |
|---|---|
| author | Patrizia Amadio Nicola Cosentino Sonia Eligini Simone Barbieri Calogero Claudio Tedesco Leonardo Sandrini Marta Zarà Franco Fabiocchi Giampaolo Niccoli Giulia Magnani Francesco Fracassi Filippo Crea Fabrizio Veglia Giancarlo Marenzi Silvia Stella Barbieri |
| author_facet | Patrizia Amadio Nicola Cosentino Sonia Eligini Simone Barbieri Calogero Claudio Tedesco Leonardo Sandrini Marta Zarà Franco Fabiocchi Giampaolo Niccoli Giulia Magnani Francesco Fracassi Filippo Crea Fabrizio Veglia Giancarlo Marenzi Silvia Stella Barbieri |
| author_sort | Patrizia Amadio |
| collection | DOAJ |
| description | Coronary artery disease (CAD) patients are at high ischemic risk, and new biomarkers reflecting atherosclerotic disease severity and coronary plaque vulnerability are required. The Brain-Derived Neurotrophic Factor (BDNF) affects endothelial and macrophage activation suggesting its involvement in atherosclerotic plaque behavior. To investigate whether plasma BDNF is associated with in vivo coronary plaque features, assessed by optical coherence tomography (OCT), in both acute myocardial infarction (AMI) and stable angina (SA) patients, we enrolled 55 CAD patients (31 SA and 24 AMI), and 21 healthy subjects (HS). BDNF was lower in CAD patients than in HS (<i>p</i> < 0.0001), and it decreased with the presence, clinical acuity and severity of CAD. The greater BDNF levels were associated with OCT features of plaque vulnerability in overall CAD as well as in SA and AMI patients (<i>p</i> < 0.03). Specifically, in SA patients, BDNF correlated positively with macrophages’ infiltration within atherosclerotic plaque (<i>p</i> = 0.01) and inversely with minimal lumen area (<i>p</i> = 0.02). In AMI patients a negative correlation between BDNF and cap thickness was found (<i>p</i> = 0.02). Despite a small study population, our data suggest a relationship between BDNF and coronary plaque vulnerability, showing that vulnerable plaque is positively associated with plasma BDNF levels, regardless of the clinical CAD manifestation. |
| first_indexed | 2024-03-10T10:49:00Z |
| format | Article |
| id | doaj.art-996487a72bcb42d0aa8e140bda6bc4f4 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T10:49:00Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-996487a72bcb42d0aa8e140bda6bc4f42023-11-21T22:22:10ZengMDPI AGDiagnostics2075-44182021-06-01116101010.3390/diagnostics11061010Potential Relation between Plasma BDNF Levels and Human Coronary Plaque MorphologyPatrizia Amadio0Nicola Cosentino1Sonia Eligini2Simone Barbieri3Calogero Claudio Tedesco4Leonardo Sandrini5Marta Zarà6Franco Fabiocchi7Giampaolo Niccoli8Giulia Magnani9Francesco Fracassi10Filippo Crea11Fabrizio Veglia12Giancarlo Marenzi13Silvia Stella Barbieri14Unit of Brain-Heart Axis: Cellular and Molecular Mechanisms, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyIntensive Cardiac Care Unit, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnit of Metabolomics and Cellular Biochemistry of Atherothrombosis, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnit of Biostatistics, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnit of Biostatistics, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnit of Brain-Heart Axis: Cellular and Molecular Mechanisms, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnit of Brain-Heart Axis: Cellular and Molecular Mechanisms, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyInterventional Cardiology Unit, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyCardiology Unit, Department of Medicine and Surgery, University of Parma, 43121 Parma, ItalyCardiology Unit, Department of Medicine and Surgery, University of Parma, 43121 Parma, ItalyDepartment of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, 00168 Rome, ItalyDepartment of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, 00168 Rome, ItalyUnit of Biostatistics, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyIntensive Cardiac Care Unit, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnit of Brain-Heart Axis: Cellular and Molecular Mechanisms, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyCoronary artery disease (CAD) patients are at high ischemic risk, and new biomarkers reflecting atherosclerotic disease severity and coronary plaque vulnerability are required. The Brain-Derived Neurotrophic Factor (BDNF) affects endothelial and macrophage activation suggesting its involvement in atherosclerotic plaque behavior. To investigate whether plasma BDNF is associated with in vivo coronary plaque features, assessed by optical coherence tomography (OCT), in both acute myocardial infarction (AMI) and stable angina (SA) patients, we enrolled 55 CAD patients (31 SA and 24 AMI), and 21 healthy subjects (HS). BDNF was lower in CAD patients than in HS (<i>p</i> < 0.0001), and it decreased with the presence, clinical acuity and severity of CAD. The greater BDNF levels were associated with OCT features of plaque vulnerability in overall CAD as well as in SA and AMI patients (<i>p</i> < 0.03). Specifically, in SA patients, BDNF correlated positively with macrophages’ infiltration within atherosclerotic plaque (<i>p</i> = 0.01) and inversely with minimal lumen area (<i>p</i> = 0.02). In AMI patients a negative correlation between BDNF and cap thickness was found (<i>p</i> = 0.02). Despite a small study population, our data suggest a relationship between BDNF and coronary plaque vulnerability, showing that vulnerable plaque is positively associated with plasma BDNF levels, regardless of the clinical CAD manifestation.https://www.mdpi.com/2075-4418/11/6/1010BDNFplaque morphologyplaque vulnerabilityOCTCADstable angina |
| spellingShingle | Patrizia Amadio Nicola Cosentino Sonia Eligini Simone Barbieri Calogero Claudio Tedesco Leonardo Sandrini Marta Zarà Franco Fabiocchi Giampaolo Niccoli Giulia Magnani Francesco Fracassi Filippo Crea Fabrizio Veglia Giancarlo Marenzi Silvia Stella Barbieri Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology Diagnostics BDNF plaque morphology plaque vulnerability OCT CAD stable angina |
| title | Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology |
| title_full | Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology |
| title_fullStr | Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology |
| title_full_unstemmed | Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology |
| title_short | Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology |
| title_sort | potential relation between plasma bdnf levels and human coronary plaque morphology |
| topic | BDNF plaque morphology plaque vulnerability OCT CAD stable angina |
| url | https://www.mdpi.com/2075-4418/11/6/1010 |
| work_keys_str_mv | AT patriziaamadio potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT nicolacosentino potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT soniaeligini potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT simonebarbieri potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT calogeroclaudiotedesco potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT leonardosandrini potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT martazara potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT francofabiocchi potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT giampaoloniccoli potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT giuliamagnani potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT francescofracassi potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT filippocrea potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT fabrizioveglia potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT giancarlomarenzi potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology AT silviastellabarbieri potentialrelationbetweenplasmabdnflevelsandhumancoronaryplaquemorphology |