Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis

Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis

<p>Abstract</p> <p>Background</p> <p>Resistance to apoptosis is a major problem in ovarian cancer and correlates with poor prognosis. Osteoprotegerin (OPG) is a secreted factor in malignant ascites and acts as a decoy receptor for receptor activator of NF-κB ligand (RAN...

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Bibliographic Details
Main Authors: Lane Denis, Matte Isabelle, Rancourt Claudine, Piché Alain
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Journal of Ovarian Research
Subjects:
Osteoprotegerin
TRAIL
Ovarian carcinoma
Resistance
Ascites
Apoptosis
Online Access:http://www.ovarianresearch.com/content/5/1/34

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