Acute Decompensated Heart Failure with Reduced Ejection Fraction: Common Etiological Cause and Predictor of Mortality in the Nepalese Population
Background: Heart failure with reduced ejection fraction (HFrEF) is one of the most common cardiac diseases causing hospital admission, with a very high short- and long-term mortality rate. The study aims to assess the short-term mortality rate of acute decompensated HFrEF and its correlation with t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Clinical and Preventive Cardiology |
| Subjects: | |
| Online Access: | http://www.jcpconline.org/article.asp?issn=2250-3528;year=2020;volume=9;issue=4;spage=155;epage=160;aulast=Nepal |
| _version_ | 1818928463495561216 |
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| author | Rajesh Nepal Manoj Kumar Choudhary Sushant Katuwal Sunil Babu Khanal Roshna Adhikari Madhav Bista Sahadev Dhungana |
| author_facet | Rajesh Nepal Manoj Kumar Choudhary Sushant Katuwal Sunil Babu Khanal Roshna Adhikari Madhav Bista Sahadev Dhungana |
| author_sort | Rajesh Nepal |
| collection | DOAJ |
| description | Background: Heart failure with reduced ejection fraction (HFrEF) is one of the most common cardiac diseases causing hospital admission, with a very high short- and long-term mortality rate. The study aims to assess the short-term mortality rate of acute decompensated HFrEF and its correlation with the baseline characteristics in a Nepalese population. Methods: Patients with acute decompensated HFrEF admitted in the unit were prospectively enrolled in this study and were followed up for 3 months. Patients who died and those who did not die were compared using the Chi-square test for categorical variables and Student's t-test was used for the comparison of continuous variables. Results: A total of 100 patients were included in the study. The mean age of the patient was 60 ± 16.18 years, with 55% of the participants being male. Atrial fibrillation was documented in 17% and 16% had bundle branch block. Idiopathic dilated cardiomyopathy was seen in 56% of the participants and was found to be the most common cause of HFrEF, followed by coronary artery disease (18%). Pleural effusion was present in 17% of the patients, out of which bilateral effusion was more common (8%). Twenty-nine percent of the patients died during the 3 months follow-up period. Dyslipidemia, hypertension, ejection fraction, baseline hemoglobin, and creatinine level were significant predictors for mortality (P < 0.05 for all). Conclusion: Dilated cardiomyopathy was the most common cause of acute decompensated HFrEF in the Nepalese population. A very high 3-month mortality rate (29%) was recorded. The presence of cardiovascular risk factors, reduced ejection fraction, baseline hemoglobin, and creatinine levels were significant predictors of mortality in acute decompensated HFrEF patients. |
| first_indexed | 2024-12-20T03:29:18Z |
| format | Article |
| id | doaj.art-996890c5308d4caf9130d02c17c584de |
| institution | Directory Open Access Journal |
| issn | 2250-3528 |
| language | English |
| last_indexed | 2024-12-20T03:29:18Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Preventive Cardiology |
| spelling | doaj.art-996890c5308d4caf9130d02c17c584de2022-12-21T19:55:01ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Preventive Cardiology2250-35282020-01-019415516010.4103/JCPC.JCPC_44_20Acute Decompensated Heart Failure with Reduced Ejection Fraction: Common Etiological Cause and Predictor of Mortality in the Nepalese PopulationRajesh NepalManoj Kumar ChoudharySushant KatuwalSunil Babu KhanalRoshna AdhikariMadhav BistaSahadev DhunganaBackground: Heart failure with reduced ejection fraction (HFrEF) is one of the most common cardiac diseases causing hospital admission, with a very high short- and long-term mortality rate. The study aims to assess the short-term mortality rate of acute decompensated HFrEF and its correlation with the baseline characteristics in a Nepalese population. Methods: Patients with acute decompensated HFrEF admitted in the unit were prospectively enrolled in this study and were followed up for 3 months. Patients who died and those who did not die were compared using the Chi-square test for categorical variables and Student's t-test was used for the comparison of continuous variables. Results: A total of 100 patients were included in the study. The mean age of the patient was 60 ± 16.18 years, with 55% of the participants being male. Atrial fibrillation was documented in 17% and 16% had bundle branch block. Idiopathic dilated cardiomyopathy was seen in 56% of the participants and was found to be the most common cause of HFrEF, followed by coronary artery disease (18%). Pleural effusion was present in 17% of the patients, out of which bilateral effusion was more common (8%). Twenty-nine percent of the patients died during the 3 months follow-up period. Dyslipidemia, hypertension, ejection fraction, baseline hemoglobin, and creatinine level were significant predictors for mortality (P < 0.05 for all). Conclusion: Dilated cardiomyopathy was the most common cause of acute decompensated HFrEF in the Nepalese population. A very high 3-month mortality rate (29%) was recorded. The presence of cardiovascular risk factors, reduced ejection fraction, baseline hemoglobin, and creatinine levels were significant predictors of mortality in acute decompensated HFrEF patients.http://www.jcpconline.org/article.asp?issn=2250-3528;year=2020;volume=9;issue=4;spage=155;epage=160;aulast=Nepalcardiovascular risk factorsheart failuremortalityreduced ejection fraction |
| spellingShingle | Rajesh Nepal Manoj Kumar Choudhary Sushant Katuwal Sunil Babu Khanal Roshna Adhikari Madhav Bista Sahadev Dhungana Acute Decompensated Heart Failure with Reduced Ejection Fraction: Common Etiological Cause and Predictor of Mortality in the Nepalese Population Journal of Clinical and Preventive Cardiology cardiovascular risk factors heart failure mortality reduced ejection fraction |
| title | Acute Decompensated Heart Failure with Reduced Ejection Fraction: Common Etiological Cause and Predictor of Mortality in the Nepalese Population |
| title_full | Acute Decompensated Heart Failure with Reduced Ejection Fraction: Common Etiological Cause and Predictor of Mortality in the Nepalese Population |
| title_fullStr | Acute Decompensated Heart Failure with Reduced Ejection Fraction: Common Etiological Cause and Predictor of Mortality in the Nepalese Population |
| title_full_unstemmed | Acute Decompensated Heart Failure with Reduced Ejection Fraction: Common Etiological Cause and Predictor of Mortality in the Nepalese Population |
| title_short | Acute Decompensated Heart Failure with Reduced Ejection Fraction: Common Etiological Cause and Predictor of Mortality in the Nepalese Population |
| title_sort | acute decompensated heart failure with reduced ejection fraction common etiological cause and predictor of mortality in the nepalese population |
| topic | cardiovascular risk factors heart failure mortality reduced ejection fraction |
| url | http://www.jcpconline.org/article.asp?issn=2250-3528;year=2020;volume=9;issue=4;spage=155;epage=160;aulast=Nepal |
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