The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/5/1462 |
| _version_ | 1797474657264205824 |
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| author | Fu-Chun Chiu Chin-Feng Tsai Pang-Shuo Huang Ching-Yu Shih Mong-Hsun Tsai Juey-Jen Hwang Yi-Chih Wang Eric Y. Chuang Chia-Ti Tsai Sheng-Nan Chang |
| author_facet | Fu-Chun Chiu Chin-Feng Tsai Pang-Shuo Huang Ching-Yu Shih Mong-Hsun Tsai Juey-Jen Hwang Yi-Chih Wang Eric Y. Chuang Chia-Ti Tsai Sheng-Nan Chang |
| author_sort | Fu-Chun Chiu |
| collection | DOAJ |
| description | Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. The variable region V3–V4 of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The metabolite amounts were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Results: The bacteria were more enriched in the AMI group both in the observed operational taxonomic units (OTUs) and faith phylogenetic diversity (PD) (<i>p</i>-value = 0.01 and <0.001 with 95% CI, individually). The <i>Selenomonadales</i> were less enriched in the AMI group at the family, genus, and species levels (all linear discriminant analysis (LDA) scores > 2). Seleno-compounds were more abundant in the AMI group at the family, genus, and species levels (all LDA scores > 2). Conclusions: This is the first study to demonstrate the association of <i>Selenomonadales</i> and seleno-compounds with the occurrence of AMI. Our findings provide an opportunity to identify a novel approach to prevent and treat AMI. |
| first_indexed | 2024-03-09T20:34:13Z |
| format | Article |
| id | doaj.art-9968f296ab8d4e8e82446fc8de31f26d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T20:34:13Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9968f296ab8d4e8e82446fc8de31f26d2023-11-23T23:16:15ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01115146210.3390/jcm11051462The Gut Microbiome, Seleno-Compounds, and Acute Myocardial InfarctionFu-Chun Chiu0Chin-Feng Tsai1Pang-Shuo Huang2Ching-Yu Shih3Mong-Hsun Tsai4Juey-Jen Hwang5Yi-Chih Wang6Eric Y. Chuang7Chia-Ti Tsai8Sheng-Nan Chang9Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City 640, TaiwanDivision of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung City 402, TaiwanDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City 640, TaiwanBioinformatics & Biostatistics Core Lab, Centers of Genomic and Precision Medicine, National Taiwan University, Taipei City 100, TaiwanBioinformatics & Biostatistics Core Lab, Centers of Genomic and Precision Medicine, National Taiwan University, Taipei City 100, TaiwanDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City 640, TaiwanDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City 100, TaiwanGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City 100, TaiwanDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City 100, TaiwanDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City 640, TaiwanBackground: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. The variable region V3–V4 of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The metabolite amounts were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Results: The bacteria were more enriched in the AMI group both in the observed operational taxonomic units (OTUs) and faith phylogenetic diversity (PD) (<i>p</i>-value = 0.01 and <0.001 with 95% CI, individually). The <i>Selenomonadales</i> were less enriched in the AMI group at the family, genus, and species levels (all linear discriminant analysis (LDA) scores > 2). Seleno-compounds were more abundant in the AMI group at the family, genus, and species levels (all LDA scores > 2). Conclusions: This is the first study to demonstrate the association of <i>Selenomonadales</i> and seleno-compounds with the occurrence of AMI. Our findings provide an opportunity to identify a novel approach to prevent and treat AMI.https://www.mdpi.com/2077-0383/11/5/1462myocardial infarctionacute coronary syndromemicrobiota<i>Selenomonadales</i>seleno-compound |
| spellingShingle | Fu-Chun Chiu Chin-Feng Tsai Pang-Shuo Huang Ching-Yu Shih Mong-Hsun Tsai Juey-Jen Hwang Yi-Chih Wang Eric Y. Chuang Chia-Ti Tsai Sheng-Nan Chang The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction Journal of Clinical Medicine myocardial infarction acute coronary syndrome microbiota <i>Selenomonadales</i> seleno-compound |
| title | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
| title_full | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
| title_fullStr | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
| title_full_unstemmed | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
| title_short | The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction |
| title_sort | gut microbiome seleno compounds and acute myocardial infarction |
| topic | myocardial infarction acute coronary syndrome microbiota <i>Selenomonadales</i> seleno-compound |
| url | https://www.mdpi.com/2077-0383/11/5/1462 |
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