Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity
A series of pyrazolines 4a-g have been synthesized by Michael addition of chalcones 3a-g with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized chalcones 3a-g and pyrazolines 4a-g have been established o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2015-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391400101A.pdf |
| _version_ | 1818806206035132416 |
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| author | Ashok Dongamanti Lakshmi Bommidi Vijaya Ravi Sidda Ganesh Arram |
| author_facet | Ashok Dongamanti Lakshmi Bommidi Vijaya Ravi Sidda Ganesh Arram |
| author_sort | Ashok Dongamanti |
| collection | DOAJ |
| description | A series of pyrazolines 4a-g have been synthesized by Michael addition of
chalcones 3a-g with hydrazine hydrate in presence of sodium acetate under
conventional heating and microwave irradiation. Structures of the newly
synthesized chalcones 3a-g and pyrazolines 4a-g have been established on the
basis of IR, 1H & 13C NMR and mass spectral data. All the synthesized
compounds were screened for their antimicrobial activity. Some of the
compounds shown very good activity compared to standard drugs against all
pathogenic bacteria and fungi. |
| first_indexed | 2024-12-18T19:06:05Z |
| format | Article |
| id | doaj.art-996c5c0a62144fe8a72bf3bc05a56877 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-18T19:06:05Z |
| publishDate | 2015-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-996c5c0a62144fe8a72bf3bc05a568772022-12-21T20:56:25ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212015-01-0180330531310.2298/JSC140021101A0352-51391400101AMicrowave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activityAshok Dongamanti0Lakshmi Bommidi Vijaya1Ravi Sidda2Ganesh Arram3Osmania University, Department of Chemistry, Hyderabad, IndiaOsmania University, Department of Chemistry, Hyderabad, IndiaOsmania University, Department of Chemistry, Hyderabad, IndiaOsmania University, Department of Chemistry, Hyderabad, IndiaA series of pyrazolines 4a-g have been synthesized by Michael addition of chalcones 3a-g with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized chalcones 3a-g and pyrazolines 4a-g have been established on the basis of IR, 1H & 13C NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial activity. Some of the compounds shown very good activity compared to standard drugs against all pathogenic bacteria and fungi.http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391400101A.pdfcoumarinchalconesMichael additionmicrowave irradiationpyrazolines |
| spellingShingle | Ashok Dongamanti Lakshmi Bommidi Vijaya Ravi Sidda Ganesh Arram Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity Journal of the Serbian Chemical Society coumarin chalcones Michael addition microwave irradiation pyrazolines |
| title | Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity |
| title_full | Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity |
| title_fullStr | Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity |
| title_full_unstemmed | Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity |
| title_short | Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity |
| title_sort | microwave assisted synthesis of some new coumarin pyrazoline hybrids and their antimicrobial activity |
| topic | coumarin chalcones Michael addition microwave irradiation pyrazolines |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2015/0352-51391400101A.pdf |
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