Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size
ObjectiveTo analyze the incidence and risk factors for lateral lymph node metastases (LNMs) in T1a papillary thyroid carcinoma (PTC) with a focus on tumor location and size.Materials and MethodsThe incidence of lateral LNM in 345 cases of T1a PTC was retrospectively analyzed. Univariate and multivar...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-07-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.716082/full |
| _version_ | 1819280845615136768 |
|---|---|
| author | Xiaojun Zhang Wenkuan Chen Qigen Fang Jie Fan Lu Feng Lanwei Guo Shanting Liu Hong Ge Wei Du |
| author_facet | Xiaojun Zhang Wenkuan Chen Qigen Fang Jie Fan Lu Feng Lanwei Guo Shanting Liu Hong Ge Wei Du |
| author_sort | Xiaojun Zhang |
| collection | DOAJ |
| description | ObjectiveTo analyze the incidence and risk factors for lateral lymph node metastases (LNMs) in T1a papillary thyroid carcinoma (PTC) with a focus on tumor location and size.Materials and MethodsThe incidence of lateral LNM in 345 cases of T1a PTC was retrospectively analyzed. Univariate and multivariate analyses were performed to assess the relationships between lateral LNM and clinicopathological characteristics.ResultsThe incidence of skip metastasis to lateral LNM in T1a PTC located in the upper lobe was 12.1% (8/66). Logistic regression analysis indicated tumor size >5 mm (OR = 5.04, 95% CI = 1.79 to 14.18, P = 0.002), upper lobe location (OR = 7.68, 95% CI = 3.05–19.34, P < 0.001) and the number of central neck LNM (<2: OR = 24.79, 95% CI = 8.23–74.60, P < 0.001; ≥2: OR = 4.99, 95% CI = 1.95–12.73, P < 0.001) were independently associated with lateral LNM. Comparing the lateral and central LNM stratification based on tumor location revealed that both the incidences of lateral (33.3%) and central (30.3%) LNM of T1a PTC located in the upper lobe were higher than those of T1a PTC located in the middle and lower lobes. Of T1a PTC located in the upper lobe, the incidence of lateral LNM was 33.3% (22/66), which was higher than that [30.3% (20/66)] of central LNM. This finding is reversed in all T1a PTC cases and T1a PTC cases with tumor located in the middle and lower lobes.ConclusionA particularly high likelihood of lateral LNM was observed in T1a PTC patients with tumor located in the upper lobe of the thyroid gland, especially the tumor >5 mm in size, which could be considered a risk factor for lateral LNM in the clinical management of T1a PTC. |
| first_indexed | 2024-12-24T00:50:16Z |
| format | Article |
| id | doaj.art-996d27e6d3d541f1a5d7b5e3ea4d0c94 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-24T00:50:16Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-996d27e6d3d541f1a5d7b5e3ea4d0c942022-12-21T17:23:36ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-07-011210.3389/fendo.2021.716082716082Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and SizeXiaojun Zhang0Wenkuan Chen1Qigen Fang2Jie Fan3Lu Feng4Lanwei Guo5Shanting Liu6Hong Ge7Wei Du8Department of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaDepartment of Head and Neck Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, ChinaDepartment of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaDepartment of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaDepartment of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaOffice for Cancer Control and Research, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaDepartment of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaDepartment of Head Neck and Thyroid Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, ChinaObjectiveTo analyze the incidence and risk factors for lateral lymph node metastases (LNMs) in T1a papillary thyroid carcinoma (PTC) with a focus on tumor location and size.Materials and MethodsThe incidence of lateral LNM in 345 cases of T1a PTC was retrospectively analyzed. Univariate and multivariate analyses were performed to assess the relationships between lateral LNM and clinicopathological characteristics.ResultsThe incidence of skip metastasis to lateral LNM in T1a PTC located in the upper lobe was 12.1% (8/66). Logistic regression analysis indicated tumor size >5 mm (OR = 5.04, 95% CI = 1.79 to 14.18, P = 0.002), upper lobe location (OR = 7.68, 95% CI = 3.05–19.34, P < 0.001) and the number of central neck LNM (<2: OR = 24.79, 95% CI = 8.23–74.60, P < 0.001; ≥2: OR = 4.99, 95% CI = 1.95–12.73, P < 0.001) were independently associated with lateral LNM. Comparing the lateral and central LNM stratification based on tumor location revealed that both the incidences of lateral (33.3%) and central (30.3%) LNM of T1a PTC located in the upper lobe were higher than those of T1a PTC located in the middle and lower lobes. Of T1a PTC located in the upper lobe, the incidence of lateral LNM was 33.3% (22/66), which was higher than that [30.3% (20/66)] of central LNM. This finding is reversed in all T1a PTC cases and T1a PTC cases with tumor located in the middle and lower lobes.ConclusionA particularly high likelihood of lateral LNM was observed in T1a PTC patients with tumor located in the upper lobe of the thyroid gland, especially the tumor >5 mm in size, which could be considered a risk factor for lateral LNM in the clinical management of T1a PTC.https://www.frontiersin.org/articles/10.3389/fendo.2021.716082/fullpapillary thyroid carcinomalymph node metastasesupper lobetumor locationtumor size |
| spellingShingle | Xiaojun Zhang Wenkuan Chen Qigen Fang Jie Fan Lu Feng Lanwei Guo Shanting Liu Hong Ge Wei Du Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size Frontiers in Endocrinology papillary thyroid carcinoma lymph node metastases upper lobe tumor location tumor size |
| title | Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size |
| title_full | Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size |
| title_fullStr | Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size |
| title_full_unstemmed | Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size |
| title_short | Lateral Lymph Node Metastases in T1a Papillary Thyroid Carcinoma: Stratification by Tumor Location and Size |
| title_sort | lateral lymph node metastases in t1a papillary thyroid carcinoma stratification by tumor location and size |
| topic | papillary thyroid carcinoma lymph node metastases upper lobe tumor location tumor size |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.716082/full |
| work_keys_str_mv | AT xiaojunzhang laterallymphnodemetastasesint1apapillarythyroidcarcinomastratificationbytumorlocationandsize AT wenkuanchen laterallymphnodemetastasesint1apapillarythyroidcarcinomastratificationbytumorlocationandsize AT qigenfang laterallymphnodemetastasesint1apapillarythyroidcarcinomastratificationbytumorlocationandsize AT jiefan laterallymphnodemetastasesint1apapillarythyroidcarcinomastratificationbytumorlocationandsize AT lufeng laterallymphnodemetastasesint1apapillarythyroidcarcinomastratificationbytumorlocationandsize AT lanweiguo laterallymphnodemetastasesint1apapillarythyroidcarcinomastratificationbytumorlocationandsize AT shantingliu laterallymphnodemetastasesint1apapillarythyroidcarcinomastratificationbytumorlocationandsize AT hongge laterallymphnodemetastasesint1apapillarythyroidcarcinomastratificationbytumorlocationandsize AT weidu laterallymphnodemetastasesint1apapillarythyroidcarcinomastratificationbytumorlocationandsize |