Risk Stratification for Bipolar Disorder Using Polygenic Risk Scores Among Young High-Risk Adults

Risk Stratification for Bipolar Disorder Using Polygenic Risk Scores Among Young High-Risk Adults

Objective: Identifying high-risk groups with an increased genetic liability for bipolar disorder (BD) will provide insights into the etiology of BD and contribute to early detection of BD. We used the BD polygenic risk score (PRS) derived from BD genome-wide association studies (GWAS) to explore how...

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Bibliographic Details
Main Authors: Silvia Biere, Thorsten M. Kranz, Silke Matura, Kristiyana Petrova, Fabian Streit, Andreas G. Chiocchetti, Oliver Grimm, Murielle Brum, Natalie Brunkhorst-Kanaan, Viola Oertel, Aliaksandr Malyshau, Andrea Pfennig, Michael Bauer, Thomas G. Schulze, Sarah Kittel-Schneider, Andreas Reif
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Psychiatry
Subjects:
polygenic risk score
bipolar disorder
genetic phenotypes
depression
ADHD
early recognition
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2020.552532/full

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