Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study
Background: Hypertrophic cardiomyopathy (HCM) is considered rare in dogs, and there is a lack of clinical data. Cardiac troponin I (cTnI) is a biomarker of cardiomyocyte damage and necrosis and can be used to diagnose cat and human HCM. Aim: We investigated whether the presence of cTnI in clinical...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tripoli University
2023-06-01
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| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | https://www.openveterinaryjournal.com/?mno=144798 |
| _version_ | 1827790883046555648 |
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| author | Takeki Ando Takeshi Izawa Hidetaka Nishida Hideo Akiyoshi |
| author_facet | Takeki Ando Takeshi Izawa Hidetaka Nishida Hideo Akiyoshi |
| author_sort | Takeki Ando |
| collection | DOAJ |
| description | Background:
Hypertrophic cardiomyopathy (HCM) is considered rare in dogs, and there is a lack of clinical data. Cardiac troponin I (cTnI) is a biomarker of cardiomyocyte damage and necrosis and can be used to diagnose cat and human HCM.
Aim:
We investigated whether the presence of cTnI in clinical data can be used in conjunction with echocardiography to diagnose canine HCM.
Methods:
This study comprised client-owned dogs with clinical evidence of concentric hypertrophy on echocardiographic images, serum total thyroxine levels of ≤5 µg/dL, systolic blood pressure of ≤180 mmHg, and absence of aortic stenosis. All cases were necropsied.
Results:
Cardiomyocyte hypertrophy (mean diameter, 18.3 ± 1.8 µm), myocardial fiber disarray (70%), interstitial fibrosis (80%), and small vessel disease (100%) were assessed. In dogs with HCM, the left ventricles were concentric, almost symmetrical, and hypertrophied above the aortic diameter. The end-diastolic interventricular septum normalized to body weight (IVSDN) was 0.788 (interquartile range [IQR], 0.7–0.92), which exceeded the normal range (5%–95%, IQR: 0.33–0.52). In total, 70% of the dogs with HCM had syncope and dispnea, and all dogs had high cardiac troponin I levels (median, 3.94 ng/mL), exceeding the upper limit of normal (0.11 ng/ml) and indicating cardiomyocyte damage. IVSDN and serum cTnI levels were correlated (p = 0.839, P = 0.01).
Conclusion:
Ventricular wall thickening and high serum cTnI levels can provide a presumptive diagnosis of HCM and prompt the initiation of treatment or additional diagnostic investigations. [Open Vet J 2023; 13(6.000): 742-752] |
| first_indexed | 2024-03-11T17:38:02Z |
| format | Article |
| id | doaj.art-996e5a2834274f8f94cb7c422aeb05c7 |
| institution | Directory Open Access Journal |
| issn | 2226-4485 |
| language | English |
| last_indexed | 2024-03-11T17:38:02Z |
| publishDate | 2023-06-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-996e5a2834274f8f94cb7c422aeb05c72023-10-18T15:29:29ZengTripoli UniversityOpen Veterinary Journal2226-44852023-06-0113674275210.5455/OVJ.2023.v13.i6.9144798Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective studyTakeki Ando0Takeshi Izawa1Hidetaka Nishida2Hideo Akiyoshi3Laboratory of Veterinary Surgery, Graduate School of Osaka Metropolitan University, Osaka 598-8531, Japan Laboratory of Veterinary Graduate School of Osaka Metropolitan University, Osaka 598-8531, Japan Laboratory of Veterinary Surgery, Graduate School of Osaka Metropolitan University, Osaka 598-8531, Japan Laboratory of Veterinary Surgery, Graduate School of Osaka Metropolitan University, Osaka 598-8531, JapanBackground: Hypertrophic cardiomyopathy (HCM) is considered rare in dogs, and there is a lack of clinical data. Cardiac troponin I (cTnI) is a biomarker of cardiomyocyte damage and necrosis and can be used to diagnose cat and human HCM. Aim: We investigated whether the presence of cTnI in clinical data can be used in conjunction with echocardiography to diagnose canine HCM. Methods: This study comprised client-owned dogs with clinical evidence of concentric hypertrophy on echocardiographic images, serum total thyroxine levels of ≤5 µg/dL, systolic blood pressure of ≤180 mmHg, and absence of aortic stenosis. All cases were necropsied. Results: Cardiomyocyte hypertrophy (mean diameter, 18.3 ± 1.8 µm), myocardial fiber disarray (70%), interstitial fibrosis (80%), and small vessel disease (100%) were assessed. In dogs with HCM, the left ventricles were concentric, almost symmetrical, and hypertrophied above the aortic diameter. The end-diastolic interventricular septum normalized to body weight (IVSDN) was 0.788 (interquartile range [IQR], 0.7–0.92), which exceeded the normal range (5%–95%, IQR: 0.33–0.52). In total, 70% of the dogs with HCM had syncope and dispnea, and all dogs had high cardiac troponin I levels (median, 3.94 ng/mL), exceeding the upper limit of normal (0.11 ng/ml) and indicating cardiomyocyte damage. IVSDN and serum cTnI levels were correlated (p = 0.839, P = 0.01). Conclusion: Ventricular wall thickening and high serum cTnI levels can provide a presumptive diagnosis of HCM and prompt the initiation of treatment or additional diagnostic investigations. [Open Vet J 2023; 13(6.000): 742-752]https://www.openveterinaryjournal.com/?mno=144798biomarkercardiac troponin idogend-diastolic thickness of the interventricular septumhypertrophic cardiomyopathy |
| spellingShingle | Takeki Ando Takeshi Izawa Hidetaka Nishida Hideo Akiyoshi Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study Open Veterinary Journal biomarker cardiac troponin i dog end-diastolic thickness of the interventricular septum hypertrophic cardiomyopathy |
| title | Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study |
| title_full | Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study |
| title_fullStr | Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study |
| title_full_unstemmed | Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study |
| title_short | Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study |
| title_sort | clinical findings using echocardiography and plasma cardiac troponin i and pathological findings in dogs with hypertrophic cardiomyopathy a retrospective study |
| topic | biomarker cardiac troponin i dog end-diastolic thickness of the interventricular septum hypertrophic cardiomyopathy |
| url | https://www.openveterinaryjournal.com/?mno=144798 |
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