Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.

Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and organ fibrosis. The pathogenesis of SSc and its progression are poorly understood. The SSc intrinsic gene expression subsets (inflammatory, fibroproliferative, normal-like, and limited) are observed in multiple...

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Bibliographic Details
Main Authors: J Matthew Mahoney, Jaclyn Taroni, Viktor Martyanov, Tammara A Wood, Casey S Greene, Patricia A Pioli, Monique E Hinchcliff, Michael L Whitfield
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4288710?pdf=render

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