Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study
The interactions between the age at onset with other pathogenic mechanisms and the interplays between the disease progression and the aging processes in Parkinson’s disease (PD) remain undefined, particularly during the first years of illness. Here, we retrospectively investigated the clinical prese...
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2023-01-01
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| Online Access: | https://www.mdpi.com/2076-3425/13/2/157 |
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| author | Lanfranco De Carolis Silvia Galli Edoardo Bianchini Domiziana Rinaldi Manikandan Raju Bianca Caliò Marika Alborghetti Francesco E. Pontieri |
| author_facet | Lanfranco De Carolis Silvia Galli Edoardo Bianchini Domiziana Rinaldi Manikandan Raju Bianca Caliò Marika Alborghetti Francesco E. Pontieri |
| author_sort | Lanfranco De Carolis |
| collection | DOAJ |
| description | The interactions between the age at onset with other pathogenic mechanisms and the interplays between the disease progression and the aging processes in Parkinson’s disease (PD) remain undefined, particularly during the first years of illness. Here, we retrospectively investigated the clinical presentation and evolution of the motor and non-motor symptoms and treatment-related complications during the first 5 years of illness in subjects categorized according to age at onset. A total of 131 subjects were divided into “Early-Onset-PD” (EOPD; onset ≤49 years), “Middle-Onset-PD” (MOPD; onset 50–69 years) and “Late-Onset-PD” (LOPD; onset ≥70 years). The T0 visit was set at the time of the clinical diagnosis; the T1 visit was 5 years (±5 months) later. At T0, there were no significant differences in the motor features among the groups. At T1, the LOPD patients displayed a significantly higher frequency of gait disturbances and a higher frequency of postural instability. Moreover, at T1, the LOPD subjects reported a significantly higher frequency of non-motor symptoms; in particular, cardiovascular, cognitive and neuropsychiatric domains. The presented results showed a significantly different progression of motor and non-motor symptoms in the early course of PD according to the age at onset. These findings contribute to the definition of the role of age at onset on disease progression and may be useful for the pharmacological and non-pharmacological management of PD. |
| first_indexed | 2024-03-11T09:05:11Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T09:05:11Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj.art-996ee918ea074ca9ae64b703c9e30c112023-11-16T19:26:58ZengMDPI AGBrain Sciences2076-34252023-01-0113215710.3390/brainsci13020157Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective StudyLanfranco De Carolis0Silvia Galli1Edoardo Bianchini2Domiziana Rinaldi3Manikandan Raju4Bianca Caliò5Marika Alborghetti6Francesco E. Pontieri7Neurology Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza—University of Rome, Sant’Andrea University Hospital, 00189 Rome, ItalyNeurology Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza—University of Rome, Sant’Andrea University Hospital, 00189 Rome, ItalyNeurology Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza—University of Rome, Sant’Andrea University Hospital, 00189 Rome, ItalyNeurology Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza—University of Rome, Sant’Andrea University Hospital, 00189 Rome, ItalyNeurology Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza—University of Rome, Sant’Andrea University Hospital, 00189 Rome, ItalyNeurology Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza—University of Rome, Sant’Andrea University Hospital, 00189 Rome, ItalyNeurology Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza—University of Rome, Sant’Andrea University Hospital, 00189 Rome, ItalyNeurology Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza—University of Rome, Sant’Andrea University Hospital, 00189 Rome, ItalyThe interactions between the age at onset with other pathogenic mechanisms and the interplays between the disease progression and the aging processes in Parkinson’s disease (PD) remain undefined, particularly during the first years of illness. Here, we retrospectively investigated the clinical presentation and evolution of the motor and non-motor symptoms and treatment-related complications during the first 5 years of illness in subjects categorized according to age at onset. A total of 131 subjects were divided into “Early-Onset-PD” (EOPD; onset ≤49 years), “Middle-Onset-PD” (MOPD; onset 50–69 years) and “Late-Onset-PD” (LOPD; onset ≥70 years). The T0 visit was set at the time of the clinical diagnosis; the T1 visit was 5 years (±5 months) later. At T0, there were no significant differences in the motor features among the groups. At T1, the LOPD patients displayed a significantly higher frequency of gait disturbances and a higher frequency of postural instability. Moreover, at T1, the LOPD subjects reported a significantly higher frequency of non-motor symptoms; in particular, cardiovascular, cognitive and neuropsychiatric domains. The presented results showed a significantly different progression of motor and non-motor symptoms in the early course of PD according to the age at onset. These findings contribute to the definition of the role of age at onset on disease progression and may be useful for the pharmacological and non-pharmacological management of PD.https://www.mdpi.com/2076-3425/13/2/157age at onsetmotor symptomsnon-motor symptomsLate-OnsetMiddle-OnsetEarly-Onset |
| spellingShingle | Lanfranco De Carolis Silvia Galli Edoardo Bianchini Domiziana Rinaldi Manikandan Raju Bianca Caliò Marika Alborghetti Francesco E. Pontieri Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study Brain Sciences age at onset motor symptoms non-motor symptoms Late-Onset Middle-Onset Early-Onset |
| title | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
| title_full | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
| title_fullStr | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
| title_full_unstemmed | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
| title_short | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
| title_sort | age at onset influences progression of motor and non motor symptoms during the early stage of parkinson s disease a monocentric retrospective study |
| topic | age at onset motor symptoms non-motor symptoms Late-Onset Middle-Onset Early-Onset |
| url | https://www.mdpi.com/2076-3425/13/2/157 |
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