The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trial
Abstract Background Probiotics increase the defense power of immune system and accelerate the wound healing process by anti-inflammatory mechanisms at the wound site. The present study aimed at evaluating the effect of Lactobacillus casei oral supplementation on episiotomy wound healing among primip...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Complementary Medicine and Therapies |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12906-023-03980-3 |
| _version_ | 1797832237674135552 |
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| author | Derakhshan Abdollahpour Aziz Homayouni-Rad Roghaiyeh Nourizadeh Sevil Hakimi Esmat Mehrabi |
| author_facet | Derakhshan Abdollahpour Aziz Homayouni-Rad Roghaiyeh Nourizadeh Sevil Hakimi Esmat Mehrabi |
| author_sort | Derakhshan Abdollahpour |
| collection | DOAJ |
| description | Abstract Background Probiotics increase the defense power of immune system and accelerate the wound healing process by anti-inflammatory mechanisms at the wound site. The present study aimed at evaluating the effect of Lactobacillus casei oral supplementation on episiotomy wound healing among primiparous women. Methods This triple-blind randomized clinical trial was performed on 74 primiparous women delivered in Alzahra Hospital, Tabriz, Iran. Participants with mediolateral episiotomy (incision length equal to and less than 5 cm) were randomly assigned to the probiotic and placebo groups. The probiotic group received Lactobacillus casei 431 with 1.5 * 109 colony-forming unit /capsule once a day from the day after birth to 14 days. Wound healing as a primary outcome was measured by Redness, Edema, Ecchymosis, Discharge, Approximation and pain as a secondary outcome by the Visual Analogue Scale before discharge, 5 ± 1 and 15 ± 1 days after birth. The data were analyzed using independent t-test and repeated measures one way analysis of variance. Results The mean (standard deviation: SD) score of wound healing in the probiotic group altered from 4.91(1.86) before discharge to 1.55 (0.99) during 5 ± 1 days after birth and reached to 0.95 (0.27) during 15 ± 1 days after birth. Further, the mean (SD) score of wound healing in the placebo group altered from 4.62 (1.99) before discharge to 2.80 (1.20) during 5 ± 1 days after birth and reached to 1.45(0.71) during 15 ± 1 days after birth (adjusted mean difference: -0.50, confidence interval 95%: -0.96 to -0.05, P = 0.03). Conclusion Lactobacillus casei oral supplementation is effective in healing episiotomy wounds. It is suggested to evaluate the effect of topical use of Lactobacillus casei on episiotomy repair and pain in further studies. Trial registration Iranian Registry of Clinical Trials (IRCT): IRCT20170506033834N7. Date of registration: 11/08/2021. |
| first_indexed | 2024-04-09T14:05:40Z |
| format | Article |
| id | doaj.art-996f7830a53c4cbdb93679ea2a1a0e2b |
| institution | Directory Open Access Journal |
| issn | 2662-7671 |
| language | English |
| last_indexed | 2024-04-09T14:05:40Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj.art-996f7830a53c4cbdb93679ea2a1a0e2b2023-05-07T11:05:19ZengBMCBMC Complementary Medicine and Therapies2662-76712023-05-012311810.1186/s12906-023-03980-3The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trialDerakhshan Abdollahpour0Aziz Homayouni-Rad1Roghaiyeh Nourizadeh2Sevil Hakimi3Esmat Mehrabi4Student Research Committee, Midwifery Department, Faculty of Nursing and Midwifery, Tabriz University of Medical SciencesDepartment of Food Science and Technology, Faculty of Nutrition & Food Science, Tabriz University of Medical SciencesMidwifery Department, Faculty of Nursing and Midwifery, Tabriz University of Medical SciencesMidwifery Department, Faculty of Nursing and Midwifery, Tabriz University of Medical SciencesMidwifery Department, Faculty of Nursing and Midwifery, Tabriz University of Medical SciencesAbstract Background Probiotics increase the defense power of immune system and accelerate the wound healing process by anti-inflammatory mechanisms at the wound site. The present study aimed at evaluating the effect of Lactobacillus casei oral supplementation on episiotomy wound healing among primiparous women. Methods This triple-blind randomized clinical trial was performed on 74 primiparous women delivered in Alzahra Hospital, Tabriz, Iran. Participants with mediolateral episiotomy (incision length equal to and less than 5 cm) were randomly assigned to the probiotic and placebo groups. The probiotic group received Lactobacillus casei 431 with 1.5 * 109 colony-forming unit /capsule once a day from the day after birth to 14 days. Wound healing as a primary outcome was measured by Redness, Edema, Ecchymosis, Discharge, Approximation and pain as a secondary outcome by the Visual Analogue Scale before discharge, 5 ± 1 and 15 ± 1 days after birth. The data were analyzed using independent t-test and repeated measures one way analysis of variance. Results The mean (standard deviation: SD) score of wound healing in the probiotic group altered from 4.91(1.86) before discharge to 1.55 (0.99) during 5 ± 1 days after birth and reached to 0.95 (0.27) during 15 ± 1 days after birth. Further, the mean (SD) score of wound healing in the placebo group altered from 4.62 (1.99) before discharge to 2.80 (1.20) during 5 ± 1 days after birth and reached to 1.45(0.71) during 15 ± 1 days after birth (adjusted mean difference: -0.50, confidence interval 95%: -0.96 to -0.05, P = 0.03). Conclusion Lactobacillus casei oral supplementation is effective in healing episiotomy wounds. It is suggested to evaluate the effect of topical use of Lactobacillus casei on episiotomy repair and pain in further studies. Trial registration Iranian Registry of Clinical Trials (IRCT): IRCT20170506033834N7. Date of registration: 11/08/2021.https://doi.org/10.1186/s12906-023-03980-3EpisiotomyLactobacillus caseiProbioticsWound healing |
| spellingShingle | Derakhshan Abdollahpour Aziz Homayouni-Rad Roghaiyeh Nourizadeh Sevil Hakimi Esmat Mehrabi The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trial BMC Complementary Medicine and Therapies Episiotomy Lactobacillus casei Probiotics Wound healing |
| title | The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trial |
| title_full | The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trial |
| title_fullStr | The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trial |
| title_full_unstemmed | The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trial |
| title_short | The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trial |
| title_sort | effect of probiotic supplementation on episiotomy wound healing among primiparous women a triple blind randomized clinical trial |
| topic | Episiotomy Lactobacillus casei Probiotics Wound healing |
| url | https://doi.org/10.1186/s12906-023-03980-3 |
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