Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans
Abstract Numerous studies have reported that antibiotics could lead to diabetes, even after adjusting for confounding variables. This study aimed to determine the causal relationship between antibiotics use and diabetes in a nationally representative cohort. This retrospective cohort study included...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01125-5 |
| _version_ | 1818856771583737856 |
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| author | Sun Jae Park Young Jun Park Jooyoung Chang Seulggie Choi Gyeongsil Lee Joung Sik Son Kyae Hyung Kim Yun Hwan Oh Sang Min Park |
| author_facet | Sun Jae Park Young Jun Park Jooyoung Chang Seulggie Choi Gyeongsil Lee Joung Sik Son Kyae Hyung Kim Yun Hwan Oh Sang Min Park |
| author_sort | Sun Jae Park |
| collection | DOAJ |
| description | Abstract Numerous studies have reported that antibiotics could lead to diabetes, even after adjusting for confounding variables. This study aimed to determine the causal relationship between antibiotics use and diabetes in a nationally representative cohort. This retrospective cohort study included adults aged 40 years or older who were enrolled in the Korean National Health Insurance Service-Health Screening Cohort. Antibiotic exposure was assessed from 2002 to 2005 and newly diagnosed diabetes mellitus was determined based on diagnostic codes and history of antidiabetic medication use from 2006 to 2015. Multivariate Cox proportional hazards model was used to assess the association between antibiotic use and diabetes incidence. The mean age of the 201,459 study subjects was 53.2 years. People who used antibiotics for 90 or more days had a higher risk of diabetes (adjusted hazard ratio [aHR] 1.16, 95% confidence interval [CI] 1.07–1.26) compared to non-users. Those who used five or more classes of antibiotics had a higher risk of diabetes than those who used one antibiotic class (aHR 1.14; 95% CI 1.06–1.23). The clear dose-dependent association between antibiotics and diabetes incidence supports the judicious use of antibiotics in the future. |
| first_indexed | 2024-12-19T08:29:48Z |
| format | Article |
| id | doaj.art-996f9e6d813f4e99a581f37a977e416e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T08:29:48Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-996f9e6d813f4e99a581f37a977e416e2022-12-21T20:29:13ZengNature PortfolioScientific Reports2045-23222021-11-0111111010.1038/s41598-021-01125-5Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among KoreansSun Jae Park0Young Jun Park1Jooyoung Chang2Seulggie Choi3Gyeongsil Lee4Joung Sik Son5Kyae Hyung Kim6Yun Hwan Oh7Sang Min Park8Department of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Family Medicine, Seoul National University Hospital, Seoul National University College of MedicineDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Family Medicine, Seoul National University Hospital, Seoul National University College of MedicineDepartment of Family Medicine, Korea University Guro HospitalDepartment of Family Medicine, Seoul National University Hospital, Seoul National University College of MedicineDepartment of Family Medicine, Jeju National University Hospital, Jeju National University College of MedicineDepartment of Biomedical Sciences, Seoul National University Graduate SchoolAbstract Numerous studies have reported that antibiotics could lead to diabetes, even after adjusting for confounding variables. This study aimed to determine the causal relationship between antibiotics use and diabetes in a nationally representative cohort. This retrospective cohort study included adults aged 40 years or older who were enrolled in the Korean National Health Insurance Service-Health Screening Cohort. Antibiotic exposure was assessed from 2002 to 2005 and newly diagnosed diabetes mellitus was determined based on diagnostic codes and history of antidiabetic medication use from 2006 to 2015. Multivariate Cox proportional hazards model was used to assess the association between antibiotic use and diabetes incidence. The mean age of the 201,459 study subjects was 53.2 years. People who used antibiotics for 90 or more days had a higher risk of diabetes (adjusted hazard ratio [aHR] 1.16, 95% confidence interval [CI] 1.07–1.26) compared to non-users. Those who used five or more classes of antibiotics had a higher risk of diabetes than those who used one antibiotic class (aHR 1.14; 95% CI 1.06–1.23). The clear dose-dependent association between antibiotics and diabetes incidence supports the judicious use of antibiotics in the future.https://doi.org/10.1038/s41598-021-01125-5 |
| spellingShingle | Sun Jae Park Young Jun Park Jooyoung Chang Seulggie Choi Gyeongsil Lee Joung Sik Son Kyae Hyung Kim Yun Hwan Oh Sang Min Park Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans Scientific Reports |
| title | Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans |
| title_full | Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans |
| title_fullStr | Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans |
| title_full_unstemmed | Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans |
| title_short | Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans |
| title_sort | association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among koreans |
| url | https://doi.org/10.1038/s41598-021-01125-5 |
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