The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy
Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of variou...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223006121 |
| _version_ | 1797822129513693184 |
|---|---|
| author | Eluri Pavitra Jyothsna Kancharla Vivek Kumar Gupta Kiran Prasad Ju Yong Sung Jigyeong Kim Mandava Bhuvan Tej Rino Choi Jeong-Hwan Lee Young-Kyu Han Ganji Seeta Rama Raju LVKS Bhaskar Yun Suk Huh |
| author_facet | Eluri Pavitra Jyothsna Kancharla Vivek Kumar Gupta Kiran Prasad Ju Yong Sung Jigyeong Kim Mandava Bhuvan Tej Rino Choi Jeong-Hwan Lee Young-Kyu Han Ganji Seeta Rama Raju LVKS Bhaskar Yun Suk Huh |
| author_sort | Eluri Pavitra |
| collection | DOAJ |
| description | Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of various genes associated with inflammation, cell progression, metastasis, and apoptosis and modulates a network of genes that underlie tumorigenesis. Herein, we focus on NF-κB signaling pathways, its regulators, and the rationale for targeting NF-κB. This review also includes TFs that maintain NF-κB crosstalk and their roles in promoting angiogenesis and metastasis. In addition, we discuss the importance of combination therapies, resistance to treatment, and potential novel therapeutic strategies including nanomedicine that targets NF-κB. |
| first_indexed | 2024-03-13T10:03:22Z |
| format | Article |
| id | doaj.art-99714ad9232042ebb80e0c7890f606b4 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T10:03:22Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-99714ad9232042ebb80e0c7890f606b42023-05-23T04:21:12ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-07-01163114822The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapyEluri Pavitra0Jyothsna Kancharla1Vivek Kumar Gupta2Kiran Prasad3Ju Yong Sung4Jigyeong Kim5Mandava Bhuvan Tej6Rino Choi7Jeong-Hwan Lee8Young-Kyu Han9Ganji Seeta Rama Raju10LVKS Bhaskar11Yun Suk Huh12NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea; 3D Convergence Center, Inha University, Incheon 22212, Republic of KoreaDepartment of Bioscience and Biotechnology, Banasthali University, Vanasthali, Rajasthan 304022, IndiaNanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of KoreaDepartment of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495009, Chhattisgarh, IndiaNanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of KoreaNanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of KoreaDepartment of Health care informatics, Sacred Heart University, 5151Park Avenue, Fair fields, CT06825, USA3D Convergence Center, Inha University, Incheon 22212, Republic of Korea; Department of Materials Science and Engineering, Inha University, Incheon 22212, Republic of Korea3D Convergence Center, Inha University, Incheon 22212, Republic of Korea; Department of Materials Science and Engineering, Inha University, Incheon 22212, Republic of KoreaDepartment of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 04620, Republic of KoreaDepartment of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 04620, Republic of Korea; Corresponding authors.Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495009, Chhattisgarh, India; Corresponding authors.NanoBio High-Tech Materials Research Center, Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea; Corresponding authors.Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of various genes associated with inflammation, cell progression, metastasis, and apoptosis and modulates a network of genes that underlie tumorigenesis. Herein, we focus on NF-κB signaling pathways, its regulators, and the rationale for targeting NF-κB. This review also includes TFs that maintain NF-κB crosstalk and their roles in promoting angiogenesis and metastasis. In addition, we discuss the importance of combination therapies, resistance to treatment, and potential novel therapeutic strategies including nanomedicine that targets NF-κB.http://www.sciencedirect.com/science/article/pii/S0753332223006121Breast cancerNF-κBChemoresistanceApoptosisAngiogenesisMetastasis |
| spellingShingle | Eluri Pavitra Jyothsna Kancharla Vivek Kumar Gupta Kiran Prasad Ju Yong Sung Jigyeong Kim Mandava Bhuvan Tej Rino Choi Jeong-Hwan Lee Young-Kyu Han Ganji Seeta Rama Raju LVKS Bhaskar Yun Suk Huh The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy Biomedicine & Pharmacotherapy Breast cancer NF-κB Chemoresistance Apoptosis Angiogenesis Metastasis |
| title | The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy |
| title_full | The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy |
| title_fullStr | The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy |
| title_full_unstemmed | The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy |
| title_short | The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy |
| title_sort | role of nf κb in breast cancer initiation growth metastasis and resistance to chemotherapy |
| topic | Breast cancer NF-κB Chemoresistance Apoptosis Angiogenesis Metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223006121 |
| work_keys_str_mv | AT eluripavitra theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT jyothsnakancharla theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT vivekkumargupta theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT kiranprasad theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT juyongsung theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT jigyeongkim theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT mandavabhuvantej theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT rinochoi theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT jeonghwanlee theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT youngkyuhan theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT ganjiseetaramaraju theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT lvksbhaskar theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT yunsukhuh theroleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT eluripavitra roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT jyothsnakancharla roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT vivekkumargupta roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT kiranprasad roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT juyongsung roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT jigyeongkim roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT mandavabhuvantej roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT rinochoi roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT jeonghwanlee roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT youngkyuhan roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT ganjiseetaramaraju roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT lvksbhaskar roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy AT yunsukhuh roleofnfkbinbreastcancerinitiationgrowthmetastasisandresistancetochemotherapy |