COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case Series
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its related disease (COVID-19) continue to represent a challenge for humans. To date, vaccination programs have represented an opportunity to navigate the pandemic. However, the advent of new genetic COVID-19 variants has increased mor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/9/891 |
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| author | Barbara Brogna Elio Bignardi Claudia Brogna Chiara Capasso Giuliano Gagliardi Alberigo Martino Lanfranco Aquilino Musto |
| author_facet | Barbara Brogna Elio Bignardi Claudia Brogna Chiara Capasso Giuliano Gagliardi Alberigo Martino Lanfranco Aquilino Musto |
| author_sort | Barbara Brogna |
| collection | DOAJ |
| description | Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its related disease (COVID-19) continue to represent a challenge for humans. To date, vaccination programs have represented an opportunity to navigate the pandemic. However, the advent of new genetic COVID-19 variants has increased more attention representing a worrying threat not only for not vaccinated but also for vaccinated people as virus infections have been shown also in the last ones. Herein, we report different clinical cases and radiological findings of COVID-19 pneumonia in six fully vaccinated patients. Two patients had a history of Rituximab therapy for follicular lymphoma and with persistent positivity for SARS-CoV-2 on nasopharyngeal/oropharyngeal (NP/OP) swabs and with moderate pneumonia on the chest computed tomography (CT). One patient who resulted to be positive to delta variant 8 days after the second vaccination dose, died shortly after. Two patients were hospitalized due to the worsening of fever and dyspnea in presence of mild pneumonia on CT. In one patient mild pneumonia was found on the chest-CT performed after a lipothymic episode associated with chest pain and positive NP/OP swab tested for SARS-CoV-2. These data suggested that in fully vaccinated people, caution should be preserved, and the use of masks and social distancing should be continued in all closed environments. However, further clinical trials should be done to better understand how various factors can influence vaccine immunogenicity as the presence of virus mutations, age factors, and the presence of an immunocompromised state. |
| first_indexed | 2024-03-10T07:28:12Z |
| format | Article |
| id | doaj.art-9971b5a1c48b4cd1a6a89bcc377c8dc6 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T07:28:12Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-9971b5a1c48b4cd1a6a89bcc377c8dc62023-11-22T14:07:51ZengMDPI AGMedicina1010-660X1648-91442021-08-0157989110.3390/medicina57090891COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case SeriesBarbara Brogna0Elio Bignardi1Claudia Brogna2Chiara Capasso3Giuliano Gagliardi4Alberigo Martino5Lanfranco Aquilino Musto6Department of Radiology, San Giuseppe Moscati Hospital, Contrada Amoretta, 83100 Avellino, ItalyRadiology Unit, “Cotugno Hospital”, Naples, Via Quagliariello 54, 80131 Naples, ItalyPediatric Neurology Unit, Fondazione Policlinico Universitario “A. Gemelli”, IRCSS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyPharmacology Department, “Frangipane” Hospital, ASL Avellino, Via V. Emanuele, 83031 Ariano Irpino, ItalyDepartment of Radiology, San Giuseppe Moscati Hospital, Contrada Amoretta, 83100 Avellino, ItalyRadiology Unit, “Frangipane” Hospital, ASL Avellino, Via V. Emanuele, 83031 Ariano Irpino, ItalyDepartment of Radiology, San Giuseppe Moscati Hospital, Contrada Amoretta, 83100 Avellino, ItalySevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its related disease (COVID-19) continue to represent a challenge for humans. To date, vaccination programs have represented an opportunity to navigate the pandemic. However, the advent of new genetic COVID-19 variants has increased more attention representing a worrying threat not only for not vaccinated but also for vaccinated people as virus infections have been shown also in the last ones. Herein, we report different clinical cases and radiological findings of COVID-19 pneumonia in six fully vaccinated patients. Two patients had a history of Rituximab therapy for follicular lymphoma and with persistent positivity for SARS-CoV-2 on nasopharyngeal/oropharyngeal (NP/OP) swabs and with moderate pneumonia on the chest computed tomography (CT). One patient who resulted to be positive to delta variant 8 days after the second vaccination dose, died shortly after. Two patients were hospitalized due to the worsening of fever and dyspnea in presence of mild pneumonia on CT. In one patient mild pneumonia was found on the chest-CT performed after a lipothymic episode associated with chest pain and positive NP/OP swab tested for SARS-CoV-2. These data suggested that in fully vaccinated people, caution should be preserved, and the use of masks and social distancing should be continued in all closed environments. However, further clinical trials should be done to better understand how various factors can influence vaccine immunogenicity as the presence of virus mutations, age factors, and the presence of an immunocompromised state.https://www.mdpi.com/1648-9144/57/9/891SARS-CoV-2COVID-19 vaccinesCOVID-19 pneumoniaimmunocompromised statecase reports |
| spellingShingle | Barbara Brogna Elio Bignardi Claudia Brogna Chiara Capasso Giuliano Gagliardi Alberigo Martino Lanfranco Aquilino Musto COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case Series Medicina SARS-CoV-2 COVID-19 vaccines COVID-19 pneumonia immunocompromised state case reports |
| title | COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case Series |
| title_full | COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case Series |
| title_fullStr | COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case Series |
| title_full_unstemmed | COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case Series |
| title_short | COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case Series |
| title_sort | covid 19 pneumonia in vaccinated population a six clinical and radiological case series |
| topic | SARS-CoV-2 COVID-19 vaccines COVID-19 pneumonia immunocompromised state case reports |
| url | https://www.mdpi.com/1648-9144/57/9/891 |
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