Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques
ObjectiveTo explore the feasibility of applying quantitative magnetic resonance imaging techniques for the diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs).MethodsA prospective study was performed by selecting 56 children aged 4–5 years with A...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1038471/full |
| _version_ | 1828290101158871040 |
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| author | Shilong Tang Xianfan Liu Lisha Nie Zhuo Chen Qiying Ran Ling He |
| author_facet | Shilong Tang Xianfan Liu Lisha Nie Zhuo Chen Qiying Ran Ling He |
| author_sort | Shilong Tang |
| collection | DOAJ |
| description | ObjectiveTo explore the feasibility of applying quantitative magnetic resonance imaging techniques for the diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs).MethodsA prospective study was performed by selecting 56 children aged 4–5 years with ADHD-ATs as the study group and 53 sex- and age-matched children with ADHD without ATs as the control group. All children underwent magnetic resonance scans with enhanced T2*- weighted magnetic resonance angiography (ESWAN), 3D-PCASL, and 3D-T1 sequences. Iron content and cerebral blood flow parameters were obtained via subsequent software processing, and the parameter values in particular brain regions in both groups were compared and analyzed to determine the characteristics of these parameters in children with ADHD-ATs.ResultsIron content and cerebral blood flow in the frontal lobe, temporal lobe, hippocampus, and caudate nucleus of children with ADHD-ATs were lower than those of children with ADHD without ATs (p < 0.05). Iron content and CBF values in the frontal lobe, temporal lobe and caudate nucleus could distinguish children with ADHD-ATs from those without ATs (AUC > 0.5, p < 0.05).ConclusionsQuantitative magnetic resonance techniques could distinguish children with ADHD-ATs.Trial registrationThis study protocol was registered at the Chinese clinical trial registry (ChiCTR2100046616). |
| first_indexed | 2024-04-13T10:31:52Z |
| format | Article |
| id | doaj.art-9972e68c9657454f8faf268d402461ed |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T10:31:52Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-9972e68c9657454f8faf268d402461ed2022-12-22T02:50:09ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-11-011310.3389/fpsyt.2022.10384711038471Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniquesShilong Tang0Xianfan Liu1Lisha Nie2Zhuo Chen3Qiying Ran4Ling He5Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaDepartment of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaGE Healthcare, MR Research China, Beijing, ChinaDepartment of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaDepartment of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaDepartment of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaObjectiveTo explore the feasibility of applying quantitative magnetic resonance imaging techniques for the diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs).MethodsA prospective study was performed by selecting 56 children aged 4–5 years with ADHD-ATs as the study group and 53 sex- and age-matched children with ADHD without ATs as the control group. All children underwent magnetic resonance scans with enhanced T2*- weighted magnetic resonance angiography (ESWAN), 3D-PCASL, and 3D-T1 sequences. Iron content and cerebral blood flow parameters were obtained via subsequent software processing, and the parameter values in particular brain regions in both groups were compared and analyzed to determine the characteristics of these parameters in children with ADHD-ATs.ResultsIron content and cerebral blood flow in the frontal lobe, temporal lobe, hippocampus, and caudate nucleus of children with ADHD-ATs were lower than those of children with ADHD without ATs (p < 0.05). Iron content and CBF values in the frontal lobe, temporal lobe and caudate nucleus could distinguish children with ADHD-ATs from those without ATs (AUC > 0.5, p < 0.05).ConclusionsQuantitative magnetic resonance techniques could distinguish children with ADHD-ATs.Trial registrationThis study protocol was registered at the Chinese clinical trial registry (ChiCTR2100046616).https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1038471/fullchildrenattention-deficit/hyperactivity disordermagnetic resonance imagingautistic traitsbrain |
| spellingShingle | Shilong Tang Xianfan Liu Lisha Nie Zhuo Chen Qiying Ran Ling He Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques Frontiers in Psychiatry children attention-deficit/hyperactivity disorder magnetic resonance imaging autistic traits brain |
| title | Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques |
| title_full | Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques |
| title_fullStr | Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques |
| title_full_unstemmed | Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques |
| title_short | Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques |
| title_sort | diagnosis of children with attention deficit hyperactivity disorder adhd comorbid autistic traits ats by applying quantitative magnetic resonance imaging techniques |
| topic | children attention-deficit/hyperactivity disorder magnetic resonance imaging autistic traits brain |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1038471/full |
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