Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinoma
Abstract Background Mohs Micrographic Surgery (MMS) is commonly used to treat high-risk basal cell carcinoma (BCC). Objectives Correlate clinicopathologic preoperative features with the number of MMS stages (primary endpoint) and margins (secondary endpoint) required for BCC complete excision. Me...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2022-06-01
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| Series: | Anais Brasileiros de Dermatologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000300291&lng=en&tlng=en |
| _version_ | 1818470825512140800 |
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| author | Joana Calvão André Pinho Ana Brinca Ricardo Vieira |
| author_facet | Joana Calvão André Pinho Ana Brinca Ricardo Vieira |
| author_sort | Joana Calvão |
| collection | DOAJ |
| description | Abstract Background Mohs Micrographic Surgery (MMS) is commonly used to treat high-risk basal cell carcinoma (BCC). Objectives Correlate clinicopathologic preoperative features with the number of MMS stages (primary endpoint) and margins (secondary endpoint) required for BCC complete excision. Methods We retrospectively analyzed BCCs treated by MMS in a 2-year period at the study’s institution. Variables studied included the patient gender, age, immune status, lesion size, location, if it was a primary, recurrent, or persistent tumor, histopathologic characteristics, number of surgical stages, and amount of tissue excised. Results 116 BCCs were included. The majority (61.2%, n = 71) required a single-stage surgery for complete clearance, requiring a final margins of 3.11 ± 2.35 mm. Statistically significant differences between locations in different high-risk areas (periocular, perioral, nose, ear) and the number of MMS stages required for complete excision (p = 0.025) were found, with periocular tumours requiring the highest mean of stages (2.29 ± 0.95). An aggressive histopathology significantly influenced the number of MMS stages (p = 0.012). Any significant relation between clinicopathological features and variation in the final surgical margins was found, just certain tendencies (male patients, persistent tumor, periocular location, and high-risk histopathological tumors required larger margins). Neither patient age or tumor dimension correlated significantly with both number of MMS stages and final surgical margins. Study limitations Limitations of this study include its single-center nature with a small sample size, which limits the value of conclusions. Conclusion Main factors related to a greater number of MMS stages were periocular location and high-risk histopathological subtype of the tumor. |
| first_indexed | 2024-04-13T21:42:45Z |
| format | Article |
| id | doaj.art-9973f1045fad4b788de0f6211ed1d5d9 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-04-13T21:42:45Z |
| publishDate | 2022-06-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-9973f1045fad4b788de0f6211ed1d5d92022-12-22T02:28:42ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962022-06-0197329129710.1016/j.abd.2021.08.007Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinomaJoana Calvãohttps://orcid.org/0000-0002-1161-269XAndré Pinhohttps://orcid.org/0000-0001-6433-311XAna Brincahttps://orcid.org/0000-0002-7539-9912Ricardo Vieirahttps://orcid.org/0000-0002-5914-9171Abstract Background Mohs Micrographic Surgery (MMS) is commonly used to treat high-risk basal cell carcinoma (BCC). Objectives Correlate clinicopathologic preoperative features with the number of MMS stages (primary endpoint) and margins (secondary endpoint) required for BCC complete excision. Methods We retrospectively analyzed BCCs treated by MMS in a 2-year period at the study’s institution. Variables studied included the patient gender, age, immune status, lesion size, location, if it was a primary, recurrent, or persistent tumor, histopathologic characteristics, number of surgical stages, and amount of tissue excised. Results 116 BCCs were included. The majority (61.2%, n = 71) required a single-stage surgery for complete clearance, requiring a final margins of 3.11 ± 2.35 mm. Statistically significant differences between locations in different high-risk areas (periocular, perioral, nose, ear) and the number of MMS stages required for complete excision (p = 0.025) were found, with periocular tumours requiring the highest mean of stages (2.29 ± 0.95). An aggressive histopathology significantly influenced the number of MMS stages (p = 0.012). Any significant relation between clinicopathological features and variation in the final surgical margins was found, just certain tendencies (male patients, persistent tumor, periocular location, and high-risk histopathological tumors required larger margins). Neither patient age or tumor dimension correlated significantly with both number of MMS stages and final surgical margins. Study limitations Limitations of this study include its single-center nature with a small sample size, which limits the value of conclusions. Conclusion Main factors related to a greater number of MMS stages were periocular location and high-risk histopathological subtype of the tumor.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000300291&lng=en&tlng=enCarcinoma, basal cellDermatologyMohs surgery |
| spellingShingle | Joana Calvão André Pinho Ana Brinca Ricardo Vieira Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinoma Anais Brasileiros de Dermatologia Carcinoma, basal cell Dermatology Mohs surgery |
| title | Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinoma |
| title_full | Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinoma |
| title_fullStr | Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinoma |
| title_full_unstemmed | Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinoma |
| title_short | Clinicopathological factors influencing the number of stages of Mohs surgery for basal cell carcinoma |
| title_sort | clinicopathological factors influencing the number of stages of mohs surgery for basal cell carcinoma |
| topic | Carcinoma, basal cell Dermatology Mohs surgery |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000300291&lng=en&tlng=en |
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