Synthesis of New Derivatives of P­ Lactam Antibiotics

New    Derivatives    for   Known    P-   Jactam  antibiotics   were synthesized  utilizing  the  free  amino  group  pres nt  in  the  parent compounds as the site for derivatization. The objectives for this study are to have new compounds which could have an increased potential resistance t...

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Bibliographic Details
Main Authors: M.D. Saud, N.F. AL- Mejwel, A. K. Sbarrad
Format: Article
Language:English
Published: University of Baghdad 2017-09-01
Series:Ibn Al-Haitham Journal for Pure and Applied Sciences
Online Access:https://jih.uobaghdad.edu.iq/index.php/j/article/view/1345
Description
Summary:New    Derivatives    for   Known    P-   Jactam  antibiotics   were synthesized  utilizing  the  free  amino  group  pres nt  in  the  parent compounds as the site for derivatization. The objectives for this study are to have new compounds which could have an increased potential resistance to the degradative enzymes knowing to be able to destroy the antibacterial activity of 13· lactam antibiotics- Besides. these new derivatives  could  be  congeners  of     known  agents,  or  may  be  a pott:ntial pro-drugs for these agents.
ISSN:1609-4042
2521-3407