Role of Obesity in Inflammation and Remodeling of Asthmatic Airway
Obesity is considered as an important risk factor for the onset of asthma and plays a key role in enhancing the disease’s severity. Obese asthmatic individuals represent a distinct phenotype of asthma that is associated with additional symptoms, more severe exacerbation, decreased response to standa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/7/948 |
| _version_ | 1797433405139320832 |
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| author | Harshita Shailesh Ibrahim A. Janahi |
| author_facet | Harshita Shailesh Ibrahim A. Janahi |
| author_sort | Harshita Shailesh |
| collection | DOAJ |
| description | Obesity is considered as an important risk factor for the onset of asthma and plays a key role in enhancing the disease’s severity. Obese asthmatic individuals represent a distinct phenotype of asthma that is associated with additional symptoms, more severe exacerbation, decreased response to standard medication, and poor quality of life. Obesity impairs the function of the lung airway in asthmatic individuals, leading to increased inflammation and severe remodeling of the bronchus; however, the molecular events that trigger such changes are not completely understood. In this manuscript, we review the current findings from studies that focused on understanding the role of obesity in modulating the functions of airway cells, including lung immune cells, epithelial cells, smooth muscle cells, and fibroblasts, leading to airway inflammation and remodeling. Finally, the review sheds light on the current knowledge of different therapeutic approaches for treating obese asthmatic individuals. Given the fact that the prevalence of asthma and obesity has been increasing rapidly in recent years, it is necessary to understand the molecular mechanisms that play a role in the disease pathophysiology of obese asthmatic individuals for developing novel therapies. |
| first_indexed | 2024-03-09T10:16:33Z |
| format | Article |
| id | doaj.art-9976f670725b44c2a87b8c5eb8c452d2 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T10:16:33Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-9976f670725b44c2a87b8c5eb8c452d22023-12-01T22:21:36ZengMDPI AGLife2075-17292022-06-0112794810.3390/life12070948Role of Obesity in Inflammation and Remodeling of Asthmatic AirwayHarshita Shailesh0Ibrahim A. Janahi1Department of Medical Education, Sidra Medicine, Doha 26999, QatarDepartment of Medical Education, Sidra Medicine, Doha 26999, QatarObesity is considered as an important risk factor for the onset of asthma and plays a key role in enhancing the disease’s severity. Obese asthmatic individuals represent a distinct phenotype of asthma that is associated with additional symptoms, more severe exacerbation, decreased response to standard medication, and poor quality of life. Obesity impairs the function of the lung airway in asthmatic individuals, leading to increased inflammation and severe remodeling of the bronchus; however, the molecular events that trigger such changes are not completely understood. In this manuscript, we review the current findings from studies that focused on understanding the role of obesity in modulating the functions of airway cells, including lung immune cells, epithelial cells, smooth muscle cells, and fibroblasts, leading to airway inflammation and remodeling. Finally, the review sheds light on the current knowledge of different therapeutic approaches for treating obese asthmatic individuals. Given the fact that the prevalence of asthma and obesity has been increasing rapidly in recent years, it is necessary to understand the molecular mechanisms that play a role in the disease pathophysiology of obese asthmatic individuals for developing novel therapies.https://www.mdpi.com/2075-1729/12/7/948obesityasthmainflammationairway remodelingairway epithelial cellsairway smooth muscle cells |
| spellingShingle | Harshita Shailesh Ibrahim A. Janahi Role of Obesity in Inflammation and Remodeling of Asthmatic Airway Life obesity asthma inflammation airway remodeling airway epithelial cells airway smooth muscle cells |
| title | Role of Obesity in Inflammation and Remodeling of Asthmatic Airway |
| title_full | Role of Obesity in Inflammation and Remodeling of Asthmatic Airway |
| title_fullStr | Role of Obesity in Inflammation and Remodeling of Asthmatic Airway |
| title_full_unstemmed | Role of Obesity in Inflammation and Remodeling of Asthmatic Airway |
| title_short | Role of Obesity in Inflammation and Remodeling of Asthmatic Airway |
| title_sort | role of obesity in inflammation and remodeling of asthmatic airway |
| topic | obesity asthma inflammation airway remodeling airway epithelial cells airway smooth muscle cells |
| url | https://www.mdpi.com/2075-1729/12/7/948 |
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