Correlation of Molecular Tumor Markers CA125, HE4, and CEA with the Development and Progression of Epithelial Ovarian Cancer
Abstract Background: This study was designed to explore the levels of serum moleculartumor markers carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4), and carcinoembryonic antigen (CEA) in patients with primary epithelial ovarian cancer, and their correlation with the progression...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2021-06-01
|
| Series: | Iranian Journal of Public Health |
| Subjects: | |
| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/22915 |
| _version_ | 1798028976414785536 |
|---|---|
| author | Qiuhua Wan Yiping Liu Bo Lv Xiaofang Chen |
| author_facet | Qiuhua Wan Yiping Liu Bo Lv Xiaofang Chen |
| author_sort | Qiuhua Wan |
| collection | DOAJ |
| description | Abstract
Background: This study was designed to explore the levels of serum moleculartumor markers carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4), and carcinoembryonic antigen (CEA) in patients with primary epithelial ovarian cancer, and their correlation with the progression of the cancer.
Methods: A total of 222 people were enrolled in this study admitted to Jining Maternal and Child Health and Family Planning Service Center from January 2016 to December 2017. There were 122 patients with primary epithelial ovarian cancer (ovarian cancer group), 50 patients with benign ovarian diseases (benign control group), and 50 healthy individuals (normal control group). The levels of serum CA125, CEA, and HE4 were detected by the electrochemical luminescence method and ELISA.
Results: The levels of serum CA125, HE4, and CEA in the ovarian cancer group were significantly higher than those in patients with the benign control group and the normal control group (P<0.01). The levels of serum CA125, HE4, and CEA in the high clinical staging group (stage III and stage II), low differentiation group, comorbid ascites group, metastasis group, and recurrence group were significantly higher than those in the low clinical staging group (stage I and stage II), high + moderate differentiation group, non-ascites group, non-metastasis group, and non-recurrence group, respectively (all P<0.05), and the levels of serum CA125, HE4, and CEA decreased significantly after treatment (P<0.01).
Conclusion: The levels of serum CA125, HE4, and CEA are closely related to the development and progression of epithelial ovarian cancer, and combined detection of CA125, HE4 and CEA is of great significance for early diagnosis, disease development monitoring, and prognosis evaluation of epithelial ovarian cancer. |
| first_indexed | 2024-04-11T19:16:56Z |
| format | Article |
| id | doaj.art-997783ca43ad49059260d9cfb90fd8ec |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-04-11T19:16:56Z |
| publishDate | 2021-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-997783ca43ad49059260d9cfb90fd8ec2022-12-22T04:07:25ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932021-06-0150610.18502/ijph.v50i6.6418Correlation of Molecular Tumor Markers CA125, HE4, and CEA with the Development and Progression of Epithelial Ovarian CancerQiuhua Wan0Yiping Liu1Bo Lv2Xiaofang Chen3Department of Clinical Laboratory, Jining Maternal and Child Health and Family Planning Service Center, Jining, 272100, ChinaPrenatal Diagnosis Center, Jining Maternal and Child Health and Family Planning Service Center, Jining, 272100, ChinaDepartment of Clinical Laboratory, Jining Maternal and Child Health and Family Planning Service Center, Jining, 272100, ChinaDepartment of Obstetrics and Gynecology, Jining Maternal and Child Health and Family Planning Service Center, Jining, 272100, ChinaAbstract Background: This study was designed to explore the levels of serum moleculartumor markers carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4), and carcinoembryonic antigen (CEA) in patients with primary epithelial ovarian cancer, and their correlation with the progression of the cancer. Methods: A total of 222 people were enrolled in this study admitted to Jining Maternal and Child Health and Family Planning Service Center from January 2016 to December 2017. There were 122 patients with primary epithelial ovarian cancer (ovarian cancer group), 50 patients with benign ovarian diseases (benign control group), and 50 healthy individuals (normal control group). The levels of serum CA125, CEA, and HE4 were detected by the electrochemical luminescence method and ELISA. Results: The levels of serum CA125, HE4, and CEA in the ovarian cancer group were significantly higher than those in patients with the benign control group and the normal control group (P<0.01). The levels of serum CA125, HE4, and CEA in the high clinical staging group (stage III and stage II), low differentiation group, comorbid ascites group, metastasis group, and recurrence group were significantly higher than those in the low clinical staging group (stage I and stage II), high + moderate differentiation group, non-ascites group, non-metastasis group, and non-recurrence group, respectively (all P<0.05), and the levels of serum CA125, HE4, and CEA decreased significantly after treatment (P<0.01). Conclusion: The levels of serum CA125, HE4, and CEA are closely related to the development and progression of epithelial ovarian cancer, and combined detection of CA125, HE4 and CEA is of great significance for early diagnosis, disease development monitoring, and prognosis evaluation of epithelial ovarian cancer.https://ijph.tums.ac.ir/index.php/ijph/article/view/22915Epithelial ovarian cancer;Carbohydrate antigenProtein |
| spellingShingle | Qiuhua Wan Yiping Liu Bo Lv Xiaofang Chen Correlation of Molecular Tumor Markers CA125, HE4, and CEA with the Development and Progression of Epithelial Ovarian Cancer Iranian Journal of Public Health Epithelial ovarian cancer; Carbohydrate antigen Protein |
| title | Correlation of Molecular Tumor Markers CA125, HE4, and CEA with the Development and Progression of Epithelial Ovarian Cancer |
| title_full | Correlation of Molecular Tumor Markers CA125, HE4, and CEA with the Development and Progression of Epithelial Ovarian Cancer |
| title_fullStr | Correlation of Molecular Tumor Markers CA125, HE4, and CEA with the Development and Progression of Epithelial Ovarian Cancer |
| title_full_unstemmed | Correlation of Molecular Tumor Markers CA125, HE4, and CEA with the Development and Progression of Epithelial Ovarian Cancer |
| title_short | Correlation of Molecular Tumor Markers CA125, HE4, and CEA with the Development and Progression of Epithelial Ovarian Cancer |
| title_sort | correlation of molecular tumor markers ca125 he4 and cea with the development and progression of epithelial ovarian cancer |
| topic | Epithelial ovarian cancer; Carbohydrate antigen Protein |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/22915 |
| work_keys_str_mv | AT qiuhuawan correlationofmoleculartumormarkersca125he4andceawiththedevelopmentandprogressionofepithelialovariancancer AT yipingliu correlationofmoleculartumormarkersca125he4andceawiththedevelopmentandprogressionofepithelialovariancancer AT bolv correlationofmoleculartumormarkersca125he4andceawiththedevelopmentandprogressionofepithelialovariancancer AT xiaofangchen correlationofmoleculartumormarkersca125he4andceawiththedevelopmentandprogressionofepithelialovariancancer |