Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci
Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated St...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/6/3283 |
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| author | Hee Jae Shin Hwa-Sun Lee Jong Seok Lee Junho Shin Min Ah Lee Hyi-Seung Lee Yeon-Ju Lee Jieun Yun Jong Soon Kang |
| author_facet | Hee Jae Shin Hwa-Sun Lee Jong Seok Lee Junho Shin Min Ah Lee Hyi-Seung Lee Yeon-Ju Lee Jieun Yun Jong Soon Kang |
| author_sort | Hee Jae Shin |
| collection | DOAJ |
| description | Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1–4) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10–26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C. |
| first_indexed | 2024-04-14T03:31:08Z |
| format | Article |
| id | doaj.art-99792cba7ac84d309c13707fb1f3df88 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T03:31:08Z |
| publishDate | 2014-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-99792cba7ac84d309c13707fb1f3df882022-12-22T02:14:58ZengMDPI AGMarine Drugs1660-33972014-05-011263283329110.3390/md12063283md12063283Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planciHee Jae Shin0Hwa-Sun Lee1Jong Seok Lee2Junho Shin3Min Ah Lee4Hyi-Seung Lee5Yeon-Ju Lee6Jieun Yun7Jong Soon Kang8Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, KoreaMarine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, KoreaBio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongwon 323-883, KoreaBio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongwon 323-883, KoreaTwo new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1–4) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10–26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.http://www.mdpi.com/1660-3397/12/6/3283Streptomyces sp.violapyronesanti-cancer activityα-pyronesstarfish |
| spellingShingle | Hee Jae Shin Hwa-Sun Lee Jong Seok Lee Junho Shin Min Ah Lee Hyi-Seung Lee Yeon-Ju Lee Jieun Yun Jong Soon Kang Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci Marine Drugs Streptomyces sp. violapyrones anti-cancer activity α-pyrones starfish |
| title | Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci |
| title_full | Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci |
| title_fullStr | Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci |
| title_full_unstemmed | Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci |
| title_short | Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci |
| title_sort | violapyrones h and i new cytotoxic compounds isolated from streptomyces sp associated with the marine starfish acanthaster planci |
| topic | Streptomyces sp. violapyrones anti-cancer activity α-pyrones starfish |
| url | http://www.mdpi.com/1660-3397/12/6/3283 |
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